Publication Name	World Journal of Gastroenterology
Manuscript ID	46489
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Case Control Study
Article Title	Risk factors for progression to acute-on-chronic liver failure during severe acute exacerbation of chronic hepatitis B virus infection
Manuscript Source	Unsolicited Manuscript
All Author List	Ling Yuan, Bai-Mei Zeng, Lu-Lu Liu, Yi Ren, Yan-Qing Yang, Jun Chu, Ying Li, Fang-Wan Yang, Yi-Huai He and Shi-De Lin
Funding Agency and Grant Number	Funding Agency Grant Number the Funds of Chinese National Natural Science Foundation Project 81460124
Corresponding Author	Shi-De Lin, MD, Chief Doctor, Occupational Physician, Professor, Department of Infectious Diseases, Affiliated Hospital of Zunyi Medical University, 201 Dalian street, Zunyi 563003, Guizhou Province, China. linshide6@zmc.edu.cn
Key Words	Acute-on-chronic liver failure; Chronic hepatitis B; Hepatic decompensation; Liver cirrhosis; Risk factors; Severe acute exacerbation
Core Tip	The risk factors related to progression in patients with severe acute exacerbation (SAE) of chronic hepatitis B virus (HBV) infection remain unknown. This is the largest study to identify the risk factors related to progression to hepatic decompensation (HD) and acute-on-chronic liver failure (ACLF) in compensated patients with SAE of chronic HBV infection. We found liver cirrhosis is an independent risk factor for progression to both HD and ACLF. High model for end-stage liver disease score, high aspartate aminotransferase, and low prothrombin activity are associated with progression to ACLF.
Citation	Yuan L, Zeng BM, Liu LL, Ren Y, Yang YQ, Chu J, Li Y, Yang FW, He YH, Lin SD. Risk factors for progression to acute-on-chronic liver failure during severe acute exacerbation of chronic hepatitis B virus infection. World J Gastroenterol 2019; 2019; 25(19): 2327-2337

Received	2019-02-14 07:59
Peer-Review Started	2019-02-17 09:33
To Make the First Decision	2019-03-20 06:45
Return for Revision	2019-03-21 07:22
Revised	2019-03-29 05:26
Second Decision	2019-04-19 07:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-04-20 02:02
Articles in Press	2019-04-20 02:02
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-04-24 13:16
Typeset the Manuscript	2019-05-20 00:46

ISSN	1007-9327 (print) and 2219-2840 (online)
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