Publication Name	World Journal of Gastroenterology
Manuscript ID	46637
Country	Spain

Category	Infectious Diseases
Manuscript Type	Opinion Review
Article Title	Fluoroquinolones for the treatment of latent Mycobacterium tuberculosis infection in liver transplantation
Manuscript Source	Invited Manuscript
All Author List	Jose Tiago Silva, Rafael San-Juan, Mario Fernandez-Ruiz and Jose Maria Aguado
Funding Agency and Grant Number	Funding Agency Grant Number “Plan Nacional de I+D+I” Instituto de Salud Carlos III (Fondo de Investigaciones Sanitarias [FIS] PI14/00174), Subdirección General de Redes y Centros de Investigación Cooperativa, Spanish Ministry of Science, Innovation and Universities, Spanish Network for Research in Infectious Diseases (REIPI RD16/0016)
Corresponding Author	Jose Tiago Silva, MD, PhD, Attending Doctor, Postdoc, Unit of Infectious Diseases, Hospital Universitario “12 de Octubre”, Instituto de Investigación Hospital “12 de Octubre” (imas12), School of Medicine, Universidad Complutense, 2ª planta, bloque D. Avda. de Córdoba, s/n, Madrid 28041, Spain. j.tiago.silva@hotmail.com
Key Words	Fluoroquinolones; Mycobacterium tuberculosis; Latent tuberculosis infection; Liver transplantation; Drug-induced liver graft injury
Core Tip	Active tuberculosis after solid organ transplantation, particularly after liver transplantation, has a dismal outcome. This review focuses on the burden of active tuberculosis after liver transplantation and summarizes the most recent data concerning the use of isoniazid for the treatment of latent tuberculosis infection in liver transplant recipients and candidates. In addition, we review the most relevant clinical experience in the use of fluoroquinolones as an alternative approach with a favorable safety profile for the treatment of latent tuberculosis infection in the liver transplant setting.
Citation	Silva JT, San-Juan R, Fernández-Ruiz M, Aguado JM. Fluoroquinolones for the treatment of latent Mycobacterium tuberculosis infection in liver transplantation. World J Gastroenterol 2019; 25(26): 3291-3298

Received	2019-02-20 05:40
Peer-Review Started	2019-02-20 07:00
To Make the First Decision	2019-04-30 10:08
Return for Revision	2019-05-05 01:13
Revised	2019-05-30 15:51
Second Decision	2019-06-05 10:31
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-06-08 15:09
Articles in Press	2019-06-08 15:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-07-13 11:42

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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