Publication Name	World Journal of Stem Cells
Manuscript ID	46673
Country	Italy

Category	Cell Biology
Manuscript Type	Review
Article Title	Orchestrating stem cell fate: Novel tools for regenerative medicine
Manuscript Source	Invited Manuscript
All Author List	Sara Cruciani, Sara Santaniello, Andrea Montella, Carlo Ventura and Margherita Maioli
Funding Agency and Grant Number
Corresponding Author	Margherita Maioli, PhD, Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, Sassari 07100, Italy. mmaioli@uniss.it
Key Words	Stem cells; Epigenetics; Self-renewal; In vitro differentiation; Physical stimuli; Stem cell fate
Core Tip	Latest advances in the field of stem cells concern epigenetics and its role in self-renewal and differentiation capability. Activation or silencing of genes controlling stemness and tissue-lineage specification are related to chromatin-remodeling factors and epigenetic regulators. In this review, we focused on the principal epigenetic markers that regulate stem cell pluripotency, in vitro manipulation and the current state-of-the-art of human mesenchymal stem cells in vivo applications.
Citation	Cruciani S, Santaniello S, Montella A, Ventura C, Maioli M. Orchestrating stem cell fate: Novel tools for regenerative medicine. World J Stem Cells 2019; 11(8):464-475

Received	2019-02-20 04:05
Peer-Review Started	2019-02-20 06:03
To Make the First Decision	2019-04-16 06:30
Return for Revision	2019-04-17 08:49
Revised	2019-05-28 06:30
Second Decision	2019-05-29 01:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-06-13 02:52
Articles in Press	2019-06-13 02:52
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-07-13 18:46
Typeset the Manuscript	2019-08-22 12:11

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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