Publication Name	World Journal of Diabetes
Manuscript ID	46683
Country	Russia

Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Recent advances and perspectives in next generation sequencing application to the genetic research of type 2 diabetes
Manuscript Source	Invited Manuscript
All Author List	Yulia A Nasykhova, Yury A Barbitoff, Elena A Serebryakova, Dmitry S Katserov and Andrey S Glotov
Funding Agency and Grant Number	Funding Agency Grant Number D.O. Ott Research Institute of Obstetrics, Gynaecology and Reproductology 558-2019-0012 of FSBSI
Corresponding Author	Andrey S Glotov, DSc, PhD, Senior Scientist, Department of Genomic Medicine, D.O. Ott Research Institute of Obstetrics, Gynaecology and Reproductology, Mendeleevskaya Line 3, St. Petersburg 199034, Russia. anglotov@mail.ru
Key Words	Type 2 diabetes; Next-generation sequencing; Epigenetics; Genome-wide association study; Microbiome
Core Tip	Next-generation sequencing (NGS) technologies have a broad range of applications in studying the genetic causes of type 2 diabetes (T2D), such as: (1) identification of rare and common genetic variants, associated with disease; (2) functional studies for describing role of genes in disease pathogenesis; and (3) evaluation of environmental contribution to the disease by using microbiome profiling methods. This review of NGS application to the genetic research of T2D presents the advances and challenges related with sequencing analysis-based studies and implementation of this knowledge in clinical practice.
Citation	Nasykhova YA, Barbitoff V, Serebryakova EA, Katserov DS, Glotov AS. Recent advances and perspectives in next generation sequencing application to the genetic research of type 2 diabetes. World J Diabetes 2019; 10(7):376-395

Received	2019-02-21 00:22
Peer-Review Started	2019-02-22 07:10
To Make the First Decision	2019-05-09 00:30
Return for Revision	2019-05-09 02:12
Revised	2019-05-23 15:52
Second Decision	2019-06-10 02:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-06-11 02:33
Articles in Press	2019-06-11 02:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-07-15 02:39

ISSN	1948-9358 (online)
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