Publication Name	World Journal of Clinical Cases
Manuscript ID	46821
Country	Romania

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Primary gastric choriocarcinoma - a rare and aggressive tumor with multilineage differentiation: A case report
Manuscript Source	Invited Manuscript
All Author List	Simona Gurzu, Constantin Copotoiu, Alexandra Tugui, Cedric Kwizera, Rita Szodorai and Ioan Jung
Funding Agency and Grant Number	Funding Agency Grant Number Romanian National Authority for Scientific Research PCCF 20/2018
Corresponding Author	Simona Gurzu, MD, PhD, Chief Doctor, Full Professor, Department of Pathology, University of Medicine, Pharmacy, Sciences and Technology, 38 Gheorghe Marinescu Street, Tirgu-Mures 530149, Romania. simonagurzu@yahoo.com
Key Words	Choriocarcinoma; Stomach; Gastrointestinal; Immunohistochemistry; Maspin; Case report
Core Tip	In this paper we presented an extremely rare histological variant of aggressive gastric carcinomas. Few than 60 cases of primary choriocarcinoma of the stomach were published in English literature. The complex immunoprofile of tumor cells, correlated with literature data, showed that gastric mucosa cells can present a multilineage differentiation and choriocarcinoma is a primary microsatellite stable adenocarcinoma without germ cell origins.
Citation	Gurzu S, Copotoiu C, Tugui A, Kwizera C, Szodorai R, Jung I. Primary gastric choriocarcinoma - a rare and aggressive tumor with multilineage differentiation: A case report. World J Clin Cases 2019; 7(14): 1837-1843

Received	2019-02-26 00:54
Peer-Review Started	2019-02-27 13:11
To Make the First Decision	2019-04-18 03:45
Return for Revision	2019-04-24 09:17
Revised	2019-05-28 13:44
Second Decision	2019-06-10 02:32
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-06-10 22:10
Articles in Press	2019-06-10 22:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-07-22 03:50

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com