Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	46900
Country	United Arab Emirates

Category	Oncology
Manuscript Type	Basic Study
Article Title	Calponin 3 promotes invasion and drug resistance of colon cancer cells
Manuscript Source	Unsolicited Manuscript
All Author List	Vidhya A Nair, Noura Al-khayyal, Sivaramakrishnan Sivaperumal and Wael M Abdel-Rahman
Funding Agency and Grant Number
Corresponding Author	Wael M Abdel-Rahman, MD, PhD, Professor, Department of Medical Laboratory Sciences, College of Health Sciences and Environment and Cancer Research Group, Sharjah Institute for Medical Research, University of Sharjah, Sharjah 27272, United Arab Emirates. whassan@sharjah.ac.ae
Key Words	β-Catenin; Calponin 3; Colon cancer; Epithelial-mesenchymal transition; Invasion; Metastasis
Core Tip	We hypothesized that Calponin 3 (CNN3) could play a role in carcinogenesis based upon its known biological functions. We showed that it is expressed in colon and breast cancer cells and it was associated with the metastatic phenotype in colon cancer via upregulating mesenchymal markers. CNN3 also improved the sensitivity to chemotherapy in these tumors. We also showed that it is linked to other carcinogenic pathways, such as extracellular signal-regulated kinase 1/2, β-Catenin, mutant p53, c-Jun, and heat shock protein 60 in colorectal cancer. Thus, CNN3 is a promising biomarker in colon cancer.
Citation	Nair VA, Al-khayyal NA, Sivaperumal S, Abdel-Rahman WM. Calponin 3 promotes invasion and drug resistance of colon cancer cells. World J Gastrointest Oncol 2019; 11(11): 971-982

Received	2019-03-06 02:25
Peer-Review Started	2019-03-08 03:26
To Make the First Decision	2019-04-16 07:33
Return for Revision	2019-05-09 09:34
Revised	2019-07-27 13:42
Second Decision	2019-09-12 10:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-09-12 21:33
Articles in Press	2019-09-12 21:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-11-05 01:33

ISSN	1948-5204 (online)
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