Publication Name	World Journal of Stem Cells
Manuscript ID	46934
Country	Japan

Category	Cell Biology
Manuscript Type	Review
Article Title	Impelling force and current challenges by chemicals in somatic cell reprogramming and expansion beyond hepatocytes
Manuscript Source	Invited Manuscript
All Author List	Jian-Yun Ge, Yun-Wen Zheng, Li-Ping Liu, Hiroko Isoda and Tatsuya Oda
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81770621 Ministry of Education, Culture, Sports, Science, and Technology of Japan, KAKENHI 16K15604, 18H02866 Japan Science and Technology Agency-Japan International Cooperation Agency's (JST-JICA) Science and Technology Research Partnership for Sustainable Development (SATREPS) Project
Corresponding Author	Yun-Wen Zheng, PhD, Associate Professor, Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery， Faculty of Medicine, University of Tsukuba Faculty of Medicine, 1-1-1 Tennodai, Tsukuba 305-8575, Ibaraki, Japan. ywzheng@md.tsukuba.ac.jp
Key Words	Chemical induction; Pluripotent reprogramming; Direct lineage conversion; Direct lineage expansion; Hepatocyte expansion; Cell fate specificity
Core Tip	Chemical-mediated reprogramming is a promising strategy for generating desired cells. However, chemical-mediated pluripotent reprogramming has reproducibility difficulties, and direct lineage conversion shows significant deficiency in cell function maturation. On the other hand, direct lineage expansion from target cells not only bypasses pluripotency-related tumorigenesis but also has superior posttransplantation advantages in engraftment and functional maturation. Recent achievements in chemical expansion of human hepatocytes may help solve the cell source limitation in liver disease treatment.
Citation	Ge JY, Zheng YW, Liu LP, Isoda H, Oda T. Impelling force and current challenges by chemicals in somatic cell reprogramming and expansion beyond hepatocytes. World J Stem Cells 2019; 11(9):650-665

Received	2019-03-02 06:14
Peer-Review Started	2019-03-04 10:57
To Make the First Decision	2019-06-05 06:25
Return for Revision	2019-06-27 01:40
Revised	2019-07-07 09:02
Second Decision	2019-08-07 00:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-08-21 05:05
Articles in Press	2019-08-21 05:05
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-09-05 23:05
Typeset the Manuscript	2019-09-12 03:23

ISSN	1948-0210 (online)
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