Publication Name	World Journal of Gastroenterology
Manuscript ID	47007
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Systems pharmacology approach reveals protective mechanisms of Jian-Pi Qing-Chang decoction on ulcerative colitis
Manuscript Source	Unsolicited Manuscript
All Author List	You-Lan Chen, Yi-Yuan Zheng, Yan-Cheng Dai, Ya-Li Zhang and Zhi-Peng Tang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Funds of China 81573892 National Natural Science Funds of China 81873253 National Natural Science Funds of China 81704009
Corresponding Author	Zhi-Peng Tang, MD, PhD, Director, Doctor, Professor, Institute of Digestive Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, No. 725 South Wanping Road, Shanghai 200032, China. zhipengtang@sohu.com
Key Words	Systems pharmacology; Ulcerative colitis; Jian-Pi Qing-Chang decoction; Inflammation; Intestinal epithelial barrier function
Core Tip	Given the complex pathogenesis of ulcerative colitis (UC), the conventional therapeutic methods are not fully curative. As a sort of systematic complementary and alternative medicine, traditional Chinese medicine (TCM) provides new options for the standard therapy. Nevertheless, there are still numerous problems with the promotion of TCM attributed to its complexity, and consequently, new research approaches are urgently needed. Thus, we explored the protective effects of Jian-Pi Qing-Chang decoction on UC based on systems pharmacology approach, which might fill the current innovation gap in drug discovery and clinical practice pertaining to TCM.
Citation	Chen YL, Zheng YY, Dai YC, Zhang YL, Tang ZP. Systems pharmacology approach reveals protective mechanisms of Jian-Pi Qing-Chang decoction on ulcerative colitis. World J Gastroenterol 2019; 25(21): 2603-2622

Received	2019-03-02 05:44
Peer-Review Started	2019-03-03 09:14
To Make the First Decision	2019-03-20 06:47
Return for Revision	2019-03-21 07:42
Revised	2019-03-27 05:42
Second Decision	2019-04-19 07:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-04-20 01:57
Articles in Press	2019-04-20 01:57
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-04-24 13:16
Typeset the Manuscript	2019-06-03 05:55

ISSN	1007-9327 (print) and 2219-2840 (online)
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