Publication Name	World Journal of Gastroenterology
Manuscript ID	47053
Country	France

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Combined evaluation of biomarkers as predictor of maintained remission in Crohn’s disease
Manuscript Source	Invited Manuscript
All Author List	Elisa Sollelis, Régine Minet-Qunard, Guillaume Bouguen, Marion Goutte, Felix Goutorbe, Damien Bouvier, Bruno Pereira, Gilles Bommelaer and Anthony Buisson
Funding Agency and Grant Number
Corresponding Author	Anthony Buisson, MD, PhD, Associate Professor, Senior Lecturer, Gastroenterology Department, University Hospital Estaing, 1 place Aubrac, Clermont-Ferrand F-63100, France. a_buisson@hotmail.fr
Key Words	Biomarkers; Crohn’s disease; Faecal calprotectin; Crohn’s disease activity index; C-reactive protein; Tight control; Anti-tumor necrosis factor
Core Tip	The CALM trial reported that a tight control of inflammation achieved better outcomes than conventional monitoring, but did not explore specifically the value of each biomarker. In this multicentre study, we investigated the performances of Crohn’s disease (CD) activity index (CDAI), C-reactive protein (CRP) and faecal calprotectin (Fcal) variation, alone or combined, after 12 wk of anti-tumor necrosis factor (TNF) therapy to predict corticosteroids-free remission (CFREM) at one year, in CD patients treated with anti-TNF. We showed the complementarity of the variation of CDAI, CRP and Fcal after anti-TNF induction therapy, to predict CFREM at one year, and confirmed that Fcal was the most effective predictor among these three markers.
Citation	Sollelis E, Quinard RM, Bouguen G, Goutte M, Goutorbe F, Bouvier D, Pereira B, Bommelaer G, Buisson A. Combined evaluation of biomarkers as predictor of maintained remission in Crohn’s disease. World J Gastroenterol 2019; 25(19): 2354-2364

Received	2019-03-07 02:05
Peer-Review Started	2019-03-07 06:15
To Make the First Decision	2019-04-11 08:58
Return for Revision	2019-04-12 02:30
Revised	2019-04-16 09:05
Second Decision	2019-04-19 07:26
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-04-20 01:52
Articles in Press	2019-04-20 01:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-05-20 00:45

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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