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Publication Name World Journal of Gastroenterology
Manuscript ID 47086
Country/Territory United Kingdom
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Eosinophils in the gastrointestinal tract and their role in the pathogenesis of major colorectal disorders
Manuscript Source Invited Manuscript
All Author List Alexandre Loktionov
Funding Agency and Grant Number
Corresponding Author Alexandre Loktionov, MD, PhD, Director, DiagNodus Ltd, 280, Babraham Research Campus, Cambridge CB22 3AT, United Kingdom. alex.loktionov@diagnodus.com
Key Words Eosinophils; Eosinophilopoiesis; Gut lamina propria; Colorectal mucus; Normal human small intestine; Normal human colon; Inflammatory bowel disease; Crohn’s disease; Ulcerative colitis; Colorectal cancer
Core Tip Eosinophils are multifunctional granulocytes possessing readily releasable stores of cytotoxic proteins, regulatory cytokines and chemokines in their specific granules. In health eosinophils reside in the gut, exerting homeostatic functions including protective mucosal barrier integrity maintenance and contribution to gut-associated immunity. Eosinophils are important players in inflammatory bowel disease pathogenesis (both Crohn’s disease and ulcerative colitis). These cells are also associated with a favourable prognosis in colorectal cancer, however mechanisms of this association remain obscure. The author presents a comprehensive analysis of the current literature on eosinophils in the gut and highlights the importance of poorly investigated immune responses occurring within colorectal mucus.
Citation Loktionov A. Eosinophils in the gastrointestinal tract and their role in the pathogenesis of major colorectal disorders. World J Gastroenterol 2019; 25(27): 3503-3526
Received
2019-03-06 06:49
Peer-Review Started
2019-03-06 08:26
To Make the First Decision
2019-05-17 00:57
Return for Revision
2019-05-20 00:50
Revised
2019-05-22 16:01
Second Decision
2019-05-30 08:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-06-01 13:21
Articles in Press
2019-06-01 13:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-07-17 00:27
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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