Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	47100
Country	Greece

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	TYMS/KRAS/BRAF molecular profiling predicts survival following adjuvant chemotherapy in colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Anastasios Ntavatzikos, Aris Spathis, Paul Patapis, Nikolaos Machairas, Georgia Vourli, George Peros, Iordanis Papadopoulos, Ioannis Panayiotides and Anna Koumarianou
Funding Agency and Grant Number	Funding Agency Grant Number National and Kapodistrian University of Athens 70/3/8006 National and Kapodistrian University of Athens 70/3/9114 PENED - European Social Fund and Greek Ministry of Development 70/3/8462
Corresponding Author	Anastasios Ntavatzikos, MD, Research Scientist, Surgeon, Teacher, Hematology-Oncology Unit, 4th Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, “ATTIKON” University Hospital, Rimini 1, Haidari, Athens 12462, Greece. dmaal2@yahoo.gr
Key Words	Colorectal neoplasms; Thymidylate synthase; Untranslated regions; Fluorouracil; KRAS; BRAF; Prognosis
Core Tip	There is a need to identify patients with colorectal cancer (CRC) who may benefit from adjuvant chemotherapy. We investigated the survival in 130 patients with stage II-III CRC treated with adjuvant chemotherapy based on thymidylate synthase (TYMS) gene polymorphisms, KRAS and BRAF status. We found that TYMS polymorphisms and BRAF status associate independently with the survival outcomes. Prospective validating studies are required.
Citation	Ntavatzikos A, Spathis A, Patapis P, Machairas N, Vourli G, Peros G, Papadopoulos I, Panayiotides I, Koumarianou A. TYMS/KRAS/BRAF molecular profiling predicts survival following adjuvant chemotherapy in colorectal cancer. World J Gastrointest Oncol 2019; 551-566

Received	2019-03-14 05:34
Peer-Review Started	2019-03-15 01:14
To Make the First Decision	2019-04-16 06:50
Return for Revision	2019-04-19 07:05
Revised	2019-04-30 09:38
Second Decision	2019-06-10 07:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-06-12 23:44
Articles in Press	2019-06-12 23:44
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-07-11 18:33
Typeset the Manuscript	2019-07-15 07:55

ISSN	1948-5204 (online)
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