Publication Name	World Journal of Stem Cells
Manuscript ID	47103
Country	Switzerland

Category	Cell Biology
Manuscript Type	Meta-Analysis
Article Title	Stem cell treatment and cerebral palsy: Systemic review and meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Simone Eggenberger, Céline Boucard, Andreina Schoeberlein, Raphael Guzman, Andreas Limacher, Daniel Surbek and Martin Muller
Funding Agency and Grant Number
Corresponding Author	Martin Muller, MD, PhD, Attending Doctor, Research Assistant Professor, Department of Obstetrics and Gynaecology, Inselspital, University Hospital Bern, Friedbühlstrasse 19, Bern 3010, Switzerland. martin.mueller@insel.ch
Key Words	Cerebral palsy; Perinatal brain injury; Stem cells; Umbilical cord blood; Mesenchymal stem/stromal cells; Gross motor function
Core Tip	Cerebral palsy is a severe motor disability resulting from perinatal complications. Recently, stem cell therapy emerged as a promising treatment option and raised hope in patients and their families. However, high-quality randomized clinical trials investigating the efficacy of stem cell therapy as a treatment for cerebral palsy are scarce. We included the small number of currently available trials in our meta-analysis. A slight but significantly positive effect on the gross motor function favoring the stem cell group can be seen.
Citation	Eggenberger S, Boucard C, Schoeberlein A, Guzman R, Limacher A, Surbek D, Mueller M. Stem cell treatment and cerebral palsy: Systemic review and meta-analysis. World J Stem Cells 2019; 11(10):891-903

Received	2019-03-12 08:00
Peer-Review Started	2019-03-15 00:15
To Make the First Decision	2019-06-05 06:49
Return for Revision	2019-06-06 06:42
Revised	2019-07-31 15:03
Second Decision	2019-07-23 06:31
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-08-21 05:00
Articles in Press	2019-08-21 05:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-10-08 05:52

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com