Publication Name	World Journal of Gastroenterology
Manuscript ID	47130
Country	Japan

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Long-lasting discussion: Adverse effects of intraoperative blood loss and allogeneic transfusion on prognosis of patients with gastric cancer
Manuscript Source	Invited Manuscript
All Author List	Koki Nakanishi, Mitsuro Kanda and Yasuhiro Kodera
Funding Agency and Grant Number
Corresponding Author	Mitsuro Kanda, MD, PhD, Doctor, Research Fellow, Surgeon, Surgical Oncologist, Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. m-kanda@med.nagoya-u.ac.jp
Key Words	Gastric cancer; Blood loss; Prognosis; Transfusion; Adverse effect; Immunosuppression; Mortality; Recurrence; Complication
Core Tip	Whether perioperative blood loss or blood transfusion has adverse effects on the prognosis in patients with gastric cancer remains unclear. We reviewed laboratory and clinical evidence of this association in patients with gastric cancer. A large amount of clinical evidence revealed that excessive intraoperative blood loss and blood transfusion have adverse effects on the prognosis. The possible mechanisms underlying the association between intraoperative blood loss and a poor prognosis are immunosuppression, unfavorable postoperative conditions, and tumor cell spillage into the pelvis, and those underlying the association between blood transfusions and a poor prognosis are immunosuppression and preoperative anemia.
Citation	Nakanishi K, Kanda M, Kodera Y. Long-lasting discussion: Adverse effects of intraoperative blood loss and allogeneic transfusion on prognosis of patients with gastric cancer. World J Gastroenterol 2019; 25(22): 2743-2751

Received	2019-03-12 06:29
Peer-Review Started	2019-03-13 01:22
To Make the First Decision	2019-03-27 05:40
Return for Revision	2019-03-27 08:01
Revised	2019-03-29 05:37
Second Decision	2019-04-19 07:29
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-04-20 01:48
Articles in Press	2019-04-20 01:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-06-13 08:32

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com