Publication Name	World Journal of Stem Cells
Manuscript ID	47161
Country	South Korea

Category	Research & Experimental Medicine
Manuscript Type	Basic Study
Article Title	Ameliorating liver fibrosis in an animal model using the secretome released from miR-122-transfected adipose-derived stem cells
Manuscript Source	Unsolicited Manuscript
All Author List	Kee-Hwan Kim, Jae Im Lee, Ok-Hee Kim, Ha-Eun Hong, Bong Jun Kwak, Ho Joong Choi, Joseph Ahn, Tae Yun Lee, Sang Chul Lee and Say-June Kim
Funding Agency and Grant Number	Funding Agency Grant Number National Research Foundation of Korea NRF-2015R1D1A1A01060721
Corresponding Author	Say-June Kim, MD, PhD, Professor, Surgeon, Department of Surgery, Seoul St. Mary’s Hospital, College of Medicine, the Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul 06591, South Korea. sayjunekim@gmail.com
Key Words	Adipose-derived stem cells; Liver fibrosis; MicroRNAs; miR-122; Mesenchymal stem cells; Secretome
Core Tip	We herein intended to determine the antifibrotic effects of the secretome released from miR-122-transfected adipose-derived stromal cells (miR-122-secretome). miR122-secrectome and naïve secretome were intravenously administered to the mice with liver fibrosis, respectively. miR122-secrectome infusion provided higher therapeutic potential in terms of reducing collagen content in the liver, inhibiting proinflammatory cytokines, and reducing abnormally elevated liver enzymes than the infusion of the naïve secretome. Proteomic analysis of the miR122-secrectome indicated that the contents of antifibrotic proteins were significantly elevated compared to those in the naïve secretome. Our results demonstrate that miR122-secrectome has higher antifibrotic and anti-inflammatory properties than the naïve secretome.
Citation	Kim KH, Lee JI, Kim OH, Hong HE, Kwak BJ, Choi HJ, Ahn J, Lee TY, Lee SC, Kim SJ. Ameliorating liver fibrosis in an animal model using the secretome released from miR-122-transfected adipose-derived stem cells. World J Stem Cells 2019; 11(11):990-1004

Received	2019-03-12 08:19
Peer-Review Started	2019-03-15 01:30
To Make the First Decision	2019-08-06 02:55
Return for Revision	2019-08-20 02:51
Revised	2019-09-02 06:49
Second Decision	2019-09-12 10:04
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2019-09-13 22:45
Articles in Press	2019-09-13 22:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-10-30 01:51

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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