Publication Name	World Journal of Gastroenterology
Manuscript ID	47330
Country	Italy

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Proton pump inhibitors and dysbiosis: Current knowledge and aspects to be clarified
Manuscript Source	Invited Manuscript
All Author List	Giovanni Bruno, Piera Zaccari, Giulia Rocco, Giulia Scalese, Cristina Panetta, Barbara Porowska, Stefano Pontone and Carola Severi
Funding Agency and Grant Number
Corresponding Author	Stefano Pontone, MD, PhD, Research Assistant Professor, Department of Surgical Sciences, Sapienza University of Rome, V.le Regina Elena 324, Rome 00161, Italy. stefano.pontone@uniroma1.it
Key Words	Proton pump inhibitors; Hypochloridria; Gut microbiota; Dysbiosis; Gastrointestinal tract; Cancer; Helicobacter pylori; Gastrointestinal infections
Core Tip	The gut microbiota plays a fundamental role in the maintenance of human health. However, several drugs, including proton pump inhibitors, can cause dysbiosis, which in turn is responsible for different extra-intestinal and intestinal diseases. An up-to-date review of the literature was conducted to identify changes in gut microbiota composition related to chronic proton pump inhibitor therapy and to highlight the possible pathogenic involvement of dysbiosis in gastrointestinal disorders.
Citation	Bruno G, Zaccari P, Rocco G, Scalese G, Panetta C, Porowska B, Pontone S, Severi C. Proton pump inhibitors and dysbiosis: Current knowledge and aspects to be clarified. World J Gastroenterol 2019; 25(22): 2706-2719

Received	2019-03-12 06:35
Peer-Review Started	2019-03-13 02:54
To Make the First Decision	2019-03-27 05:41
Return for Revision	2019-03-27 08:12
Revised	2019-04-02 15:42
Second Decision	2019-04-19 07:31
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-04-20 01:47
Articles in Press	2019-04-20 01:47
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-06-13 08:28

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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