Publication Name	World Journal of Gastroenterology
Manuscript ID	47535
Country	Greece

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Inflammatory bowel diseases and spondyloarthropathies: From pathogenesis to treatment
Manuscript Source	Invited Manuscript
All Author List	George E Fragoulis, Christina Liava, Dimitrios Daoussis, Evangelos Akriviadis, Alexandros Garyfallos and Theodoros Dimitroulas
Funding Agency and Grant Number
Corresponding Author	Theodoros Dimitroulas, MD, PhD, Assistant Professor, 4th Department of Internal Medicine, Hippocration Hospital, School of Medicine, Aristotle University of Thessaloniki, 49 Konstantinoupoleos str., Thessaloniki 54642, Greece. dimitroul@hotmail.com
Key Words	Spondyloarthropathies; Axial spondyloarthropathies; Peripheral spondyloarthropathies; Ankylosing spondylitis; Inflammatory bowel disease
Core Tip	Spondyloarthropathies (SpA) are subdivided to axial and peripheral SpA with ankylosing spondylitis (AS) being the prototype disease of the former. They have many extra-articular manifestations the most common of which is bowel involvement. Inflammatory bowel disease (IBD) (silent or clinically evident) occurs much more frequently in AS compared to the general population and associates with AS disease activity. Both axial and peripheral SpA occur more frequently in Crohn’s disease than ulcerative colitis. Pathogenetic mechanisms that have been proposed to explain the link between SpA and IBD include dysregulated microbiome and migration of T lymphocytes and other cells from gut to the joint.
Citation	Fragoulis GE, Liava C, Daoussis D, Akriviadis E, Garyfallos A, Dimitroulas T. Inflammatory bowel diseases and spondyloarthropathies: From pathogenesis to treatment. World J Gastroenterol 2019; 25(18): 2162-2176

Received	2019-03-22 01:53
Peer-Review Started	2019-03-22 06:25
To Make the First Decision	2019-04-08 00:46
Return for Revision	2019-04-08 07:21
Revised	2019-04-11 20:40
Second Decision	2019-04-19 07:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-04-20 01:44
Articles in Press	2019-04-20 01:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-05-14 00:29

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com