Publication Name	World Journal of Clinical Oncology
Manuscript ID	47622
Country	Spain

Category	Oncology
Manuscript Type	Review
Article Title	Management of oligometastatic non-small cell lung cancer patients: Current controversies and future directions
Manuscript Source	Invited Manuscript
All Author List	Felipe Couñago, Javier Luna, Luis Leonardo Guerrero, Blanca Vaquero, María Cecilia Guillén-Sacoto, Teresa González-Merino, Begoña Taboada, Verónica Díaz, Belén Rubio-Viqueira, Ana Aurora Díaz-Gavela, Francisco José Marcos and Elia del Cerro
Funding Agency and Grant Number
Corresponding Author	Felipe Couñago, MD, PhD, Doctor, Professor, Staff Physician, Department of Radiation Oncology, Hospital Universitario Quirónsalud Madrid, Calle Diego de Velázquez 1, Pozuelo de Alarcón, Madrid 28223, Spain. fcounago@gmail.com
Key Words	Non-small cell lung cancer; Metastasectomy; Oligometastases; Stereotactic ablative radiotherapy; Stereotactic body radiation therapy; Radiosurgery
Core Tip	In recent years, numerous studies, including two randomized phase II trials, have demonstrated that local treatment-either radiotherapy or surgery-of the primary tumour and metastases improves progression-free survival and overall survival in patients who present with oligometastatic non-small cell lung cancer at diagnosis and in those who respond to the initial systemic therapy. As we await the results of ongoing randomized phase III trials, the main international clinical guidelines recommend a multimodal strategy to manage this subgroup of oligometastatic patients. Current guidelines recommend systemic therapy combined with local treatment of the metastases and, if applicable, the primary tumour.
Citation	Couñago F, Luna J, Guerrero LL, Vaquero B, Guillen-Sacoto MC, González-Merino T, Taboada B, Díaz V, Rubio-Viqueira B, Díaz-Gavela AA, Marcos FJ, del Cerro E. Management of oligometastatic non-small cell lung cancer patients: Current controversies and future directions. World J Clin Oncol 2019; 10(9): 318-339

Received	2019-03-19 01:12
Peer-Review Started	2019-03-19 14:07
To Make the First Decision	2019-08-06 06:37
Return for Revision	2019-08-08 07:56
Revised	2019-08-30 09:26
Second Decision	2019-09-04 07:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-09-15 17:39
Articles in Press	2019-09-15 17:39
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-09-27 23:40
Typeset the Manuscript	2019-10-23 07:07

ISSN	2218-4333 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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