Publication Name	World Journal of Stem Cells
Manuscript ID	47678
Country	United States

Category	Orthopedics
Manuscript Type	Review
Article Title	Dysfunctional stem and progenitor cells impair fracture healing with age
Manuscript Source	Invited Manuscript
All Author List	Diane R Wagner, Sonali Karnik, Zachary Gunderson, Jeffery Nielsen, Alanna Fennimore, Hunter Promer, Jonathan Lowery, M Terry Loghmani, Philip S Low, Todd McKinley, Melissa A Kacena, Matthias Clauss and Jiliang Li
Funding Agency and Grant Number	Funding Agency Grant Number Indiana University Collaborative Research Grant Indiana Clinical and Translational Sciences Institute NIH UL1TR001108 National Institutes of Health R01 AR069657 National Institutes of Health R01 AR060863 National Institutes of Health R01 AG060621 Veteran's Affairs BX003751
Corresponding Author	Diane R Wagner, PhD, Associate Professor, Department of Mechanical and Energy Engineering, Indiana University-Purdue University Indianapolis, 723 W. Michigan St. SL 260, Indianaposlis, IN 46202, United States. wagnerdi@iupui.edu
Key Words	Fracture healing; Aging; Bone; Angiogenesis; Mesenchymal stem cells; Endothelial progenitor cells
Core Tip	Bone fractures in the elderly are a significant issue, due to the prevalence of the problem, the difficulty of treatment, and the severe consequences of the extended healing period. The delay in fracture healing with advanced age has been attributed to both the decreased number and function of mesenchymal stem cells that regenerate the bone and the inferior performance of endothelial progenitor cells that direct angiogenesis. Some suggested avenues for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics.
Citation	Wagner DR, Karnik S, Gunderson ZJ, Nielsen JJ, Fennimore A, Promer HJ, Lowery JW, Loghmani MT, Low PS, McKinley TO, Kacena MA, Clauss M, Li J. Dysfunctional stem and progenitor cells impair fracture healing with age. World J Stem Cells 2019; 11(6): 281-296

Received	2019-03-21 05:34
Peer-Review Started	2019-03-22 09:14
To Make the First Decision	2019-04-24 06:00
Return for Revision	2019-04-24 08:19
Revised	2019-04-26 23:08
Second Decision	2019-05-29 01:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-06-13 02:33
Articles in Press	2019-06-13 02:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-06-24 01:58

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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