Publication Name	World Journal of Gastroenterology
Manuscript ID	47784
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Lingguizhugan decoction attenuates diet-induced obesity and hepatosteatosis via gut microbiota
Manuscript Source	Unsolicited Manuscript
All Author List	Meng-Ting Liu, Ying-Juan Huang, Ting-Ying Zhang, Lun-Bo Tan, Xi-Feng Lu and Jian Qin
Funding Agency and Grant Number	Funding Agency Grant Number the National Natural Science Foundation of China No.81874498
Corresponding Author	Jian Qin, MD, PhD, Doctor, Professor, Department of Traditional Chinese Medicine, the Seventh Affiliated Hospital of Sun Yat-Sen University, No. 628, Zhenyuan Road, Guangming New District, Shenzhen 510080, Guangdong Province, China. jian.qin.sunyatsen@outlook.com
Key Words	Obesity; Diabetes; Lipid metabolism; Hepatosteatosis; Gut microbiota
Core Tip	This study shows that caloric restriction (CR) together with Lingguizhugan decoction (LZD) only slightly reduce body weight and blood glucose levels of normal diet (ND)-fed mice. Yet, transplanting the fecal microbiota of these mice into high-fat diet (HFD)-fed mice potently attenuated diet-induced obesity, hepatic steatosis, and hyperglycemia. Moreover, we found that fecal microbiota transplantation (FMT) increases oxygen consumption rate of the mice and suppresses hepatic lipid biosynthesis. Using metagenomic sequencing, we further discovered that CR and LZD treatment alters the profile of ND-fed mice, and FMT alters HFD-induced changes in gut microbiota. Taken together, our study highlights that CR and LZD treatment exerts its metabolic improving effects via modulating gut microbiota.
Citation	Liu MT, Huang YJ, Zhang TY, Tan LB, Lu XF, Qin J. Lingguizhugan decoction attenuates diet-induced obesity and hepatosteatosis via gut microbiota. World J Gastroenterol 2019; 25(27): 3590-3606

Received	2019-03-25 06:13
Peer-Review Started	2019-03-26 03:10
To Make the First Decision	2019-05-17 00:23
Return for Revision	2019-05-24 06:16
Revised	2019-05-30 11:04
Second Decision	2019-06-05 10:36
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-06-08 14:59
Articles in Press	2019-06-08 14:59
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-06-21 21:34
Typeset the Manuscript	2019-07-17 00:52

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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