Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	47832
Country	Italy

Category	Surgery
Manuscript Type	Minireviews
Article Title	Neoadjuvant therapy in the treatment of hilar cholangiocarcinoma: Review of the literature
Manuscript Source	Invited Manuscript
All Author List	Fabio Frosio, Federico Mocchegiani, Grazia Conte, Enrico Dalla Bona, Andrea Vecchi, Daniele Nicolini and Marco Vivarelli
Funding Agency and Grant Number
Corresponding Author	Federico Mocchegiani, MD, Assistant Professor, Unit of Hepato-pancreato-biliary and Transplant Surgery, Department of Experimental and Clinical Medicine, Polytechnic University of Marche, Via Conca 71, Ancona 60126, Italy. federicomocchegiani@hotmail.com
Key Words	Hilar cholangiocarcinoma; Klatskin tumor; Neoadjuvant treatement; Radiotherapy; Chemotherapy; Hepatic resection; Liver transplantation
Core Tip	Surgery is the only potentially curative treatment for hilar cholangiorcinoma; however, most of the patients are considered not resectable because of the local extent. Neoadjuvant radiochemotherapy is supposed to increase R0 margins rate, or even to allow radical resection for locally advanced tumors, but few studies are available. Moreover, for patients with early stage tumors meeting the Mayo Clinic criteria, neoadjuvant therapy before liver transplantation has produced very good survivals, gaining worldwide acceptance. This is the first review to consider the role of neoadjuvant treatment for hilar cholangiocarcinoma, before resection as well as before liver transplantation.
Citation	Frosio F, Mocchegiani F, Conte G, Dalla Bona E, Vecchi A, Nicolini D, Vivarelli M. Neoadjuvant therapy in the treatment of hilar cholangiocarcinoma: Review of the literature. World J Gastrointest Surg 2019; 11(6): 279-286

Received	2019-03-26 00:25
Peer-Review Started	2019-03-28 09:41
To Make the First Decision	2019-05-09 00:21
Return for Revision	2019-05-09 02:21
Revised	2019-05-29 23:39
Second Decision	2019-06-10 02:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-06-10 22:07
Articles in Press	2019-06-10 22:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-06-27 01:08

ISSN	1948-9366 (online)
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