Publication Name	World Journal of Stem Cells
Manuscript ID	48075
Country	Australia

Category	Oncology
Manuscript Type	Minireviews
Article Title	The Role of bioactive lipids in cancer stem cells
Manuscript Source	Invited Manuscript
All Author List	Romana-Rea Begicevic, Frank Arfuso and Marco Falasca
Funding Agency and Grant Number
Corresponding Author	Marco Falasca, MSc, PhD, Professor, Research Scientist, School of Pharmacy and Biomedical Sciences, Curtin Health Innovation, Curtin University, GPO Box U1987, Perth 6102, WA, Australia. marco.falasca@curtin.edu.au
Key Words	Cancer stem cells; Lipid metabolism; Bioactive lipids; ABC transporters; ;
Core Tip	Cancer stem cells (CSCs) are a minute portion of highly aggressive cells that survive conventional and targeted therapies and ultimately re-populate the tumour. Recent studies have elucidated that SCD1 and HMG-CoA metabolic pathways involved in lipid metabolism are hyperactive in CSCs. However, the purpose of this enhanced activity is unclear. Here, we review the current literature and discuss the possible pathways and mechanisms that link the enhanced CSC lipid metabolism to bioactivity. Specifically, with regard to structural lipids and active bio-molecules involved in cell signalling.
Citation	Begicevic RR, Arfuso F, Falasca M. Bioactive lipids in cancer stem cells. World J Stem Cells 2019; 11(9):693-704

Received	2019-04-09 01:54
Peer-Review Started	2019-04-12 06:23
To Make the First Decision	2019-06-05 06:21
Return for Revision	2019-06-27 01:23
Revised	2019-07-08 01:48
Second Decision	2019-08-07 00:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-08-21 04:23
Articles in Press	2019-08-21 04:23
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-08-30 00:58
Typeset the Manuscript	2019-09-18 11:05

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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