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Publication Name World Journal of Gastroenterology
Manuscript ID 48232
Country/Territory Italy
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Ex vivo effect of vascular wall stromal cells secretome on enteric ganglia
Manuscript Source Unsolicited Manuscript
All Author List Giovanni Dothel, Chiara Bernardini, Augusta Zannoni, Maria Rosaria Spirito, Roberta Salaroli, Maria Laura Bacci, Monica Forni and Fabrizio De Ponti
Funding Agency and Grant Number
Funding Agency Grant Number
Fondazione del Monte di Bologna e Ravenna FdM/3208
Corresponding Author Monica Forni, PhD, Associate Professor, Professor, Department of Veterinary Medical Sciences, University of Bologna, Via Tolara di Sopra 50, Ozzano dell'Emilia, Bologna 40064, Italy. monica.forni@unibo.it
Key Words Enteric nervous system; Mesenchymal stromal cells; Inflammatory bowel disease; Ganglia; Translational models;
Core Tip Secretome of porcine vascular wall mesenchymal stromal cells (pVW-MSCs) induced an increase of glial cell number in swine and guinea pig-derived enteric ganglia. Co-treatment of enteric ganglia with lipopolysaccharide and conditioned medium promoted glial cell differentiation only in pigs. These data indicate an immune activation promoted by pVW-MSCs which could be more specific in higher mammals, suggesting a careful consideration of the animal models used in research studies on cell-based therapies.
Citation Dothel G, Bernardini C, Zannoni A, Spirito MR, Salaroli R, Bacci ML, Forni M, De Ponti F. Ex vivo effect of vascular wall stromal cells secretome on enteric ganglia. World J Gastroenterol 2019; 25(33): 4892-4903
Received
2019-04-11 00:37
Peer-Review Started
2019-04-11 05:34
To Make the First Decision
2019-05-17 00:26
Return for Revision
2019-05-24 06:44
Revised
2019-05-31 10:10
Second Decision
2019-06-05 10:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-06-08 14:56
Articles in Press
2019-06-08 14:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-09-04 01:08
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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