Publication Name	World Journal of Clinical Cases
Manuscript ID	48438
Country	United States

Category	Pathology
Manuscript Type	Minireviews
Article Title	Multifocal G1-G2 gastric neuroendocrine tumors: Differentiating between Type I, II and III, a clinicopathologic review
Manuscript Source	Invited Manuscript
All Author List	Khaled Algashaamy and Monica Garcia-Buitrago
Funding Agency and Grant Number
Corresponding Author	Khaled Algashaamy, MBBS, MD, Doctor, Department of Pathology and Laboratory medicine, Jackson Memorial Hospital, University of Miami, Miller School of medicine, Holtz Center, 1611 NW 12th Avenue, Suite 2044, Miami, FL 33136, United States. khaled.algashaamy@jhsmiami.org
Key Words	Gastric neuroendocrine tumors; Enterochromaffin like cells; Histopathological features; Immunohistochemistry; Diagnosis; Treatment
Core Tip	Gastric neuroendocrine tumors are a rare entity with increasing incidence. Different pathophysiological processes can lead to the development of these tumors, appropriate histological analysis is necessary to differentiate between grade 1 (G1) and grade 2 (G2) tumors as this will impact the management of these patients based on their increased risk of lymph node and distant metastases. In this mini-review article, we aim to provide a comprehensive clinicopathologic review of multifocal gastric neuroendocrine tumors, with particular emphasis on G1 and G2 tumors and differentiating between types I, II and II and risk stratification based upon immunohistochemical profile. We have based this review on peer-reviewed literature and the authors’ experience.
Citation	Algashaamy K, Garcia-Buitrago M. Multifocal G1-G2 gastric neuroendocrine tumors: Differentiating between Type I, II and III, a clinicopathologic review. World J Clin Cases 2019; 7(17):2413-2419

Received	2019-04-23 01:16
Peer-Review Started	2019-05-08 03:49
To Make the First Decision	2019-06-03 03:14
Return for Revision	2019-06-17 02:53
Revised	2019-07-26 12:30
Second Decision	2019-08-16 10:31
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-08-20 04:07
Articles in Press	2019-08-20 04:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-09-05 07:14

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BYNC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is noncommercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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