Publication Name	World Journal of Clinical Cases
Manuscript ID	48556
Country	South Korea

Category	Engineering, Biomedical
Manuscript Type	Prospective Study
Article Title	Immediate muscle strengthening by an end-effector type gait robot with reduced real-time use of leg muscles: A case series and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Chang Ho Hwang
Funding Agency and Grant Number	Funding Agency Grant Number Future Growth Engine Flagship Project 1711034791 the National Research Foundation of Korea 2017R1A2B4011478
Corresponding Author	Chang Ho Hwang, MD, PhD, Full Professor, Physical Medicine and RehAbilitation, Ulsan University Hospital, University of Ulsan College of Medicine, 877 Bangeojinsunhwando-ro, Dong-gu, Ulsan University Hospital, Ulsan 44033, Ulsan, South Korea. chhwang1220ciba@gmail.com
Key Words	Robotics; Rehabilitation; Muscles; Neuronal plasticity; Gait; Knee
Core Tip	Just five-minute end-effector type robot-assisted gait training with non-weight bearing on their feet and 100% guidance force may induce immediate strengthening of the knee flexor and extensor muscles. Moreover, it may even reduce the real-time use of the thigh and calf muscles. It may be a useful tool to strengthen the leg muscles in the elderly or in patients with musculoskeletal injuries. As for its underlying mechanism, author supposes the rapid brain and spinal plasticity in theory.
Citation	Hwang CH. Immediate muscle strengthening by an end-effector type gait robot with reduced real-time use of leg muscles: A case series and review of literature. World J Clin Cases 2019; 7(19):2976-2985

Received	2019-04-24 00:40
Peer-Review Started	2019-05-08 04:02
To Make the First Decision	2019-08-02 03:34
Return for Revision	2019-08-15 02:34
Revised	2019-08-27 07:48
Second Decision	2019-09-12 08:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-09-12 19:14
Articles in Press	2019-09-12 19:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-09-24 11:19

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com