Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	48680
Country	Japan

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Immune checkpoint inhibitor-induced diarrhea/colitis: Endoscopic and pathologic findings
Manuscript Source	Invited Manuscript
All Author List	Tsutomu Nishida, Hideki Iijima and Shiro Adachi
Funding Agency and Grant Number
Corresponding Author	Tsutomu Nishida, MD, PhD, Doctor, Department of Gastroenterology, Toyonaka Municipal Hospital, 4-14-1 Shibahara, Toyonaka, Osaka 560-8565, Japan. tnishida.gastro@gmail.com
Key Words	Immune checkpoint inhibitor; Colitis; Diarrhea; Endoscopic; Pathologic;
Core Tip	Immune checkpoint inhibitor (ICPI)-induced colitis/diarrhea is frequent and recognized not only by oncologists but also by gastroenterologists or endoscopists. The endoscopic findings resemble those of inflammatory bowel disease to a certain extent, particularly ulcerative colitis, but are not identical. The pathological findings of ICPI-induced colitis may vary among drug classes. The findings show acute or chronic phases but may depend on the diagnostic timing or treatment intervention. Colonoscopy with biopsy is necessary to confirm ICPI-induced colitis, and early evaluation may avoid exacerbating or prolonging colitis due to treatment resistance.
Citation	Nishida T, Iijima H, Adachi S. Immune checkpoint inhibitor-induced diarrhea/colitis: Endoscopic and pathologic findings. World J Gastrointest Pathophysiol 2019; 10(2): 17-28

Received	2019-04-28 01:54
Peer-Review Started	2019-05-09 02:21
To Make the First Decision	2019-06-13 02:13
Return for Revision	2019-06-17 03:32
Revised	2019-06-30 23:56
Second Decision	2019-08-21 03:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-08-21 18:54
Articles in Press	2019-08-21 18:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-09-05 03:54

ISSN	2150-5330 (online)
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