Publication Name	World Journal of Gastroenterology
Manuscript ID	48771
Country	Italy

Category	Gastroenterology & Hepatology
Manuscript Type	Systematic Reviews
Article Title	De novo malignancies after liver transplantation: The effect of immunosuppression-personal data and review of literature
Manuscript Source	Invited Manuscript
All Author List	Tommaso Maria Manzia, Roberta Angelico, Carlo Gazia, Ilaria Lenci, Martina Milana, Oludamilola T Ademoyero, Domiziana Pedini, Luca Toti, Marco Spada, Giuseppe Tisone and Leonardo Baiocchi
Funding Agency and Grant Number
Corresponding Author	Tommaso Maria Manzia, MD, PhD, Assistant Professor, Hepato-Pancreato-Biliary and Transplant, Department of Surgery, University of Rome Tor Vergata, Viale Oxford, 81, Rome 00133, Italy. tomanzia@libero.it
Key Words	Pediatric liver transplant; Immunosuppression weaning; Clinical operational tolerance; Adult liver transplant; Graft rejection; Immune system
Core Tip	A systematic literature examination about the current state-of-the-art on de novo malignancies and immunosuppression weaning both in adult and pediatric orthotopic liver transplants recipients was described in the present review. Even if, conclusive evidences on immunosuppression withdrawal in orthotopic liver transplants recipients with regard to malignancies, are lacking we can argue that the reconstitution of immunological pathway could decrease the incidence of de novo malignancies and may also help in treating liver transplanted patients suffering from cancers.
Citation	Manzia TM, Angelico R, Gazia C, Lenci I, Milana M, Ademoyero OT, Pedini D, Toti L, Spada M, Tisone G, Baiocchi L. De novo malignancies after liver transplantation: The effect of immunosuppression-personal data and review of literature. World J Gastroenterol 2019; 25(35): 5356-5375

Received	2019-05-02 06:14
Peer-Review Started	2019-05-04 09:33
To Make the First Decision	2019-05-31 00:55
Return for Revision	2019-06-06 01:28
Revised	2019-08-08 12:11
Second Decision	2019-08-23 10:07
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-08-24 04:50
Articles in Press	2019-08-24 04:50
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-09-01 23:07
Typeset the Manuscript	2019-09-17 01:27

ISSN	1007-9327 (print) and 2219-2840 (online)
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