Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	49368
Country	China

Category	Genetics & Heredity
Manuscript Type	Basic Study
Article Title	Identification of candidate biomarkers correlated with pathogenesis of postoperative peritoneal adhesion by using microarray analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Yao-Yao Bian, Li-Li Yang, Yan Yan, Min Zhao, Yan-Qi Chen, Ya-Qi Zhou, Zi-Xin Wang, Wen-Lin Li and Li Zeng
Funding Agency and Grant Number	Funding Agency Grant Number the National Natural Science Foundation of China 81704084 the National Natural Science Foundation of China 81603529 the National Natural Science Foundation of China 81673982 the Science and Technology Projects of Jiangsu Provincial Bureau of Traditional Chinese Medicine YB2017002 the Science and Technology Projects of Jiangsu Provincial Bureau of Traditional Chinese Medicine YB2015002 the Natural Science Foundation of the Jiangsu Higher Education Institutions 16KJB360002 the Postgraduate Research and Practice Innovation Program of Jiangsu Province KYCX18_1541 Qing Lan Project Chinese Medicine Advantage Discipline Funding Project and China Scholarship Council
Corresponding Author	Li Zeng, PhD, Academic Research, Professor, School of First Clinical Medicine and Jingwen Library, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, Jiangsu Province, China. zengli@njucm.edu.cn
Key Words	Postoperative peritoneal adhesion; Candidate biomarkers; Molecular pathogenesis; Bioinformatics analysis; ;
Core Tip	Postoperative peritoneal adhesion (PPA) remains an urgent clinical concern due to the increasing abdominal surgery. The occurrence and formation of adhesion come from a complex biological process. However, the molecular mechanisms on the basis of microarray data profile, followed by peritoneal adhesion formation, are largely unknown. In this study, we uncovered the underlying pathogenesis of PPA in molecular levels using bioinformatics analysis methods. The results were further validated using animal experiment. It showed that regulatory evidences chain of TLR4/MyD88/NF-κB/inflammatory cytokines/peritoneal adhesion played key roles in the pathogenesis of postoperative adhesion. Our findings may provide new cues of peritoneal adhesion formation.
Citation	Bian YY, Yang LL, Yan Y, Zhao M, Chen YQ, Zhou YQ, Wang ZX, Li WL, Zeng L. Identification of candidate biomarkers correlated with pathogenesis of postoperative peritoneal adhesion by using microarray analysis. World J Gastrointest Oncol 2020; 12(1): 54-65

Received	2019-06-01 06:00
Peer-Review Started	2019-06-04 07:52
To Make the First Decision	2019-08-01 00:05
Return for Revision	2019-08-02 07:53
Revised	2019-08-05 12:36
Second Decision	2019-09-12 10:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-09-13 04:27
Articles in Press	2019-09-13 04:27
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-10-13 20:35
Typeset the Manuscript	2019-12-02 07:45

ISSN	1948-5204 (online)
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