| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Long noncoding RNA-associated competing endogenous RNA and regulatory mechanism of LINC02407 in human gastric adenocarcinoma
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Li Zhou, Yan Jiao, Hong-Mei Chen, Li-Hua Kang, Qi Yang, Jing Li, Meng Guan, Ge Zhu, Fei-Qi Liu, Shuang Wang, Xue Bai and Yan-Qiu Song |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| science and technology department of Jilin province |
20160101028JC |
| Special funds of provincial strategic adjustment of economic structure to guide in Jilin Province |
2014G074 |
|
| Corresponding Author |
Yan-Qiu Song, MD, PhD, Academic Research, Director, Doctor, Full Professor, Professor, Teacher, Cancer Center, The First Hospital of Jilin University, NO.71 XinMin street, Changchun 130021, Jilin Province, China. song_yq@jlu.edu.cn |
| Key Words |
Gastric cancer; Long noncoding RNAs; LINC02407; Adhesion G protein-coupled receptor D1; MicroRNA-6845-5p; MicroRNA-4455 |
| Core Tip |
A series of long noncoding RNA were differentially expressed in gastric cancer (GC), which some including LINC02407 had significant impacts on the prognosis of patients. Experiments in vitro showed that LINC02407 was significantly upregulated in GC cell lines and tissue samples, and could promote the proliferation and migration, inhibit apoptosis of GC cells. Mechanism research found that LINC02407 can regulate the expression of adhesion G protein-coupled receptor D1 by targeting miR-6845-5p and miR-4455, increased the malignancy of GC cells eventually. Our study provides evidence that LINC02407 may be an important oncogene and has potential value in GC diagnosis and treatment. |
| Citation |
Zhou LL, Jiao Y, Chen HM, Kang LH, Yang Q, Li J, Guan M, Zhu G, Liu FQ, Wang S, Bai X, Song YQ. Long noncoding RNA-associated competing endogenous RNA and regulatory mechanism of LINC02407 in human gastric adenocarcinoma. World J Gastroenterol 2019; 25(39): 5973-5990 |
