Publication Name	World Journal of Hepatology
Manuscript ID	49450
Country	Brazil

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Hepatocellular carcinoma staging systems: Hong Kong liver cancer vs Barcelona clinic liver cancer in a Western population
Manuscript Source	Unsolicited Manuscript
All Author List	Laura Bainy Rodrigues de Freitas, Larisse Longo, Deivid Santos, Ivana Grivicich and Mário Reis Álvares-da-Silva
Funding Agency and Grant Number
Corresponding Author	Laura Bainy Rodrigues de Freitas, MD, Medical Assistant, Graduate Program in Gastroenterology and Hepatology, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-003, RS, Brazil. laurabrfreitas@gmail.com
Key Words	Barcelona clinic liver cancer staging system; Hepatocellular carcinoma; Hong Kong liver cancer staging system; ; ;
Core Tip	Despite being the world’s most widely used system for staging and therapeutic guidance in hepatocellular carcinoma (HCC) treatment, the Barcelona clinic liver cancer (BCLC) system has limitation. Proposed Hong Kong liver cancer (HKLC) staging appears useful but requires validation in Western populations. This study showed that there is adequate agreement between the HKLC and BCLC systemsregarding therapeutic management of HCC in Western populations, except in cases of intermediate HCC. Although staging systems should be further refined to cover the full diversity of HCC cases, these findings suggest that the BCLC system, which is more simple and intuitive, should be applied in all HCC cases, and that in BCLC-A and, especially, BCLC-B cases, the HKLC can contribute important information regarding patient management.
Citation	de Freitas LBR, Longo L, Santos D, Grivicich I, Álvares-da-Silva MR. Hepatocellular carcinoma staging systems: HKLC vs BCLC in a Western population. World J Hepatol 2019; 11(9): 678-688

Received	2019-05-28 00:19
Peer-Review Started	2019-05-29 02:21
To Make the First Decision	2019-06-14 00:58
Return for Revision	2019-06-18 06:27
Revised	2019-07-08 21:12
Second Decision	2019-08-16 12:15
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-08-20 23:07
Articles in Press	2019-08-20 23:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-09-07 06:31

ISSN	1948-5182 (online)
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