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9/13/2019 4:17:09 AM | Browse: 205 | Download: 344
Publication Name World Journal of Gastroenterology
Manuscript ID 49533
Country/Territory China
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Up-regulated Wnt1-inducible signaling pathway protein-1 correlates with poor prognosis and drug-resistance by reducing DNA repair in gastric cancer
Manuscript Source Unsolicited Manuscript
All Author List Li-Hua Zhang, Yan Wang, Long-Hai Li, Qian-Qian Fan, Yan-Kui Liu, Xiao-Wei Qi, Yong Mao and Dong Hua
Funding Agency and Grant Number
Corresponding Author Dong Hua, MD, PhD, Chief Doctor, Professor, Department of Oncology, Affiliated Hospital of Jiangnan University, No. 200 Huihe Road, Wuxi 214062, Jiangsu Province, China. wx89211@163.com
Key Words Wnt1-inducible signaling pathway protein-1; Biomarker; Bioinformatics analysis; Chemotherapy outcome; Gastric cancer;
Core Tip The present study for the first time revealed that Significantly upregulated Wnt1-inducible signaling pathway protein-1 (WISP1) expression was associated with advanced cancer, drug resistance and poor prognosis in gastric cancer (GC). WISP1 enhanced oxaliplatin resistance by reducing cell cytotoxicity through enhancing DNA repair. Overall, the findings of the present study suggest that WISP1 is a novel prognostic biomarker for GC and highlight the significance of WISP1 as promising therapeutic targets for GC.
Citation Zhang LH, Wang Y, Li LH, Fan QQ, Liu YK, Qi XW, Mao Y, Hua D. Up-regulated Wnt1-inducible signaling pathway protein-1 correlates with poor prognosis and drug-resistance by reducing DNA repair in gastric cancer. World J Gastroenterol 2019; 25(38): 5814-5825
Received
2019-06-01 05:58
Peer-Review Started
2019-06-03 07:59
To Make the First Decision
2019-07-22 03:21
Return for Revision
2019-07-24 02:25
Revised
2019-08-16 16:58
Second Decision
2019-09-12 09:41
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-09-13 04:17
Articles in Press
2019-09-13 04:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-09-24 12:05
Typeset the Manuscript
2019-10-14 07:46
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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