Publication Name	World Journal of Orthopedics
Manuscript ID	49724
Country	Greece

Category	Orthopedics
Manuscript Type	Basic Study
Article Title	Effect of clopidogrel in bone healing-experimental study in rabbits
Manuscript Source	Invited Manuscript
All Author List	Theodoros Lillis, Alexander Veis, Nikolaos Sakellaridis, Anastasios Tsirlis and Zoe H Dailiana
Funding Agency and Grant Number
Corresponding Author	Zoe H Dailiana, MD, PhD, Professor, Surgeon, Department of Orthopaedic Surgery, Faculty of Medicine, University of Thessalia, 3 Panepistimiou St., Larissa 41500, Greece. dailiana@med.uth.gr
Key Words	Clopidogrel; Bone healing; Purinergic signaling; Calvarial defect; Rabbit;
Core Tip	To our knowledge, the present study is the first to evaluate the effect of clopidogrel treatment on bone healing. Clopidogrel is an antithrombotic drug that inhibits platelet aggregation through inhibition of the P2Y12 purinergic receptor on their surface. The P2Y12 is also expressed in osteoblasts and osteoclasts, and previous studies have raised concerns about clopidogrel’s possible effect on bone metabolism. We report our results on the effect of clopidogrel on bone healing using the rabbit calvarial defect model. Our results indicate that clopidogrel treatment not only does not negatively affect bone healing, but rather promotes it.
Citation	Lillis T, Veis A, Sakellaridis N, Tsirlis A, Dailiana Z. Effect of clopidogrel in bone healing-experimental study in rabbits. World J Orthop 2019; 10(12): 434-445

Received	2019-06-11 00:41
Peer-Review Started	2019-06-11 08:16
To Make the First Decision	2019-07-31 06:07
Return for Revision	2019-08-07 01:57
Revised	2019-08-27 23:07
Second Decision	2019-08-30 11:52
Accepted by Journal Editor-in-Chief	2019-09-01 05:24
Accepted by Company Editor-in-Chief	2019-09-16 00:55
Articles in Press	2019-09-16 00:55
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-09-21 02:52
Typeset the Manuscript	2019-12-02 02:01

ISSN	2218-5836 (online)
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