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Articles in Press
8/21/2019 1:25:01 AM | Browse: 330 | Download: 370
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Editorial |
Article Title |
New era for pancreatic endoscopic ultrasound: From imaging to molecular pathology of pancreatic cancer
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Manuscript Source |
Invited Manuscript |
All Author List |
Livia Archibugi, Sabrina Gloria Giulia Testoni, Miriam Redegalli, Maria Chiara Petrone, Michele Reni, Massimo Falconi, Claudio Doglioni, Gabriele Capurso and Paolo Giorgio Arcidiacono |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Associazione Italiana Ricerca sul Cancro (AIRC) |
IG 17177 |
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Corresponding Author |
Gabriele Capurso, MD, PhD, Chief Doctor, Pancreato-Biliary Endoscopy and EUS Division, Pancreas Translational and Clinical Research Center, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milano 20132, Italy. capurso.gabriele@hsr.it |
Key Words |
Endoscopic ultrasound; Pancreatic cancer; Ribonucleic acid; Deoxyribonucleic acid; Mutation; Molecular |
Core Tip |
Surgical formalin-fixed-paraffin-embedded samples are not representative of all pancreatic ductal adenocarcinoma (PDAC) patients and it was proved how “pre-resection” fine-needle aspiration smears are a better deoxyribonucleic acid (DNA) source. endoscopic ultrasound (EUS) is therefore the recommended method to obtain tumour’s molecular signature analysis. However, important limitations of EUS-acquired samples are: intratumoral heterogeneity, tumoral cells total amount and lesional-to-non-lesional cell ratio. Furthermore, sample handling and stock change DNA and even more ribonucleic acid extraction efficiency, a current “hot topic” as also patient-derived xenografts or organoids generation. Optimization and standardization of procedures from EUS-guided biopsy to samples handling and molecular analyses are, therefore, essential to allow a “precision medicine” for PDAC. |
Citation |
Archibugi L, Testoni SGG, Redegalli M, Petrone MC, Reni M, Falconi M, Doglioni C, Capurso G, Arcidiacono PG. New era for pancreatic endoscopic ultrasound: From imaging to molecular pathology of pancreatic cancer. World J Gastrointest Oncol 2019; 11(11): 933-945 |
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Received |
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2019-06-15 09:37 |
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Peer-Review Started |
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2019-06-19 09:31 |
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To Make the First Decision |
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2019-08-01 00:23 |
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Return for Revision |
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2019-08-01 08:38 |
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Revised |
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2019-08-01 14:33 |
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Second Decision |
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2019-08-16 09:37 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2019-08-21 01:25 |
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Articles in Press |
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2019-08-21 01:25 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-09-19 03:43 |
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Typeset the Manuscript |
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2019-10-24 12:21 |
ISSN |
1948-5204 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
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