Publication Name	World Journal of Gastroenterology
Manuscript ID	50061
Country	Italy

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Sarcopenia and cognitive impairment in liver cirrhosis: A viewpoint on the clinical impact of minimal hepatic encephalopathy
Manuscript Source	Invited Manuscript
All Author List	Silvia Nardelli, Stefania Gioia, Jessica Faccioli, Oliviero Riggio and Lorenzo Ridola
Funding Agency and Grant Number
Corresponding Author	Lorenzo Ridola, MD, PhD, Doctor, Department of Translational and Precision Medicine, “Sapienza” University of Rome, viale dell’Università 37, Rome 00185, Italy. lorenzo.ridola@uniroma1.it
Key Words	Minimal hepatic encephalopathy; Cognitive impairment; Sarcopenia; Muscle alterations; Cirrhosis;
Core Tip	Minimal hepatic encephalopathy (MHE) represents the mildest type of hepatic encephalopathy, is very frequent, affecting from 20% up to 80% of patients tested, depending of the diagnostic tools used and has been related to the patients’ falls, fitness to drive, and working ability. As a consequence, MHE affects the patients and caregivers lives by altering their quality of life and even their socioeconomic status. Sarcopenia has been recently proposed as a risk factor for both minimal and overt Hepatic Encephalopathy. Aim of this review is to summarize the most recently published evidences about the emerging relationship between sarcopenia and cognitive impairment.
Citation	Nardelli S, Gioia S, Faccioli J, Riggio O, Ridola L. Sarcopenia and cognitive impairment in liver cirrhosis: A viewpoint on the clinical impact of minimal hepatic encephalopathy. World J Gastroenterol 2019; 25(35): 5257-5265

Received	2019-07-02 01:49
Peer-Review Started	2019-07-02 07:44
To Make the First Decision	2019-08-05 01:36
Return for Revision	2019-08-08 07:27
Revised	2019-08-08 10:56
Second Decision	2019-08-23 10:23
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-08-24 04:43
Articles in Press	2019-08-24 04:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-09-17 01:22

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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