Publication Name	World Journal of Gastroenterology
Manuscript ID	50161
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Sirtuin 1 alleviates the endoplasmic reticulum stress-mediated apoptosis of intestinal epithelial cells in ulcerative colitis
Manuscript Source	Unsolicited Manuscript
All Author List	Meng-Ting Ren, Meng-Li Gu, Xin-Xin Zhou, Mo-Sang Yu, Hang-Hai Pan, Feng Ji and Chen-Yan Ding
Funding Agency and Grant Number	Funding Agency Grant Number the National Nature Science Foundation of China 81600414 the Natural Science Foundation of Zhejiang Province LQ16H030001 Zhejiang TCM Science and Technology Project 2016ZA123 Zhejiang TCM Science and Technology Project 2018ZA013
Corresponding Author	Xin-Xin Zhou, MD, Attending Doctor, Department of Gastroenterology, The First Affiliated Hospital,College of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. zhouxinxin@zju.edu.cn
Key Words	Sirtuin 1; Endoplasmic reticulum stress; Apoptosis; Ulcerative colitis; Intestinal barrier;
Core Tip	The purpose of this article is to investigate the role of sirtuin 1 (SIRT1) in intestinal epithelial cells (IECs) in ulcerative colitis (UC) in a UC coculture model and in mice with dextran sodium sulfate (DSS)-induced colitis. It was found that SIRT1 activation contributes to enhanced intestinal barrier and reduced apoptosis of IECs via the suppression of the endoplasmic reticulum stress-mediated apoptosis-associated molecules CCAAT/enhancer-binding protein homologous protein and caspase-12. SIRT1 activation may be a potential therapeutic strategy for UC.
Citation	Ren MT, Gu ML, Zhou XX, Yu MS, Pan HH, Ji F, Ding CY. Sirtuin 1 alleviates the endoplasmic reticulum stress-mediated apoptosis of intestinal epithelial cells in ulcerative colitis. World J Gastroenterol 2019; 25(38): 5800-5813

Received	2019-07-16 16:09
Peer-Review Started	2019-07-17 08:18
To Make the First Decision	2019-08-05 01:38
Return for Revision	2019-08-16 02:41
Revised	2019-08-30 12:27
Second Decision	2019-09-12 09:55
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-09-13 04:13
Articles in Press	2019-09-13 04:13
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-09-24 12:06
Typeset the Manuscript	2019-10-14 07:39

ISSN	1007-9327 (print) and 2219-2840 (online)
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