Publication Name	World Journal of Clinical Oncology
Manuscript ID	50169
Country	Spain

Category	Oncology
Manuscript Type	Editorial
Article Title	Are all prostate cancer patients "fit" for salvage radiotherapy?
Manuscript Source	Invited Manuscript
All Author List	Carmen González-San Segundo, Alfonso Gómez-Iturriaga and Felipe Couñago
Funding Agency and Grant Number
Corresponding Author	Carmen González-San Segundo, MD, PhD, Professor, Research Scientist, Staff Physician, Department of Radiation Oncology, HGU Gregorio Marañon, Complutense University, C/Doctor Esquerdo 46, Madrid 28007, Spain. cglezss@gmail.com
Key Words	Prostate cancer; Salvage radiotherapy; Comorbidity; Fit; Androgen deprivation therapy;
Core Tip	Salvage radiotherapy (SRT) is an effective treatment for biochemically-recurrent prostate cancer after prostatectomy. Proper patient selection is crucial. While tumour-related factors are important, the indication for SRT should also be based on clinical factors and dosimetric variables. Patients with non-aggressive tumours who have a life expectancy of less than 10 years are unlikely to benefit from radiotherapy and should thus be considered "unfit" for SRT. The development of advanced imaging techniques such Ga-PSMA positron emission tomography/computed tomography, which are capable of localizing the recurrent lesion when prostate-specific antigen ≤ 0.5 ng/mL, has forced clinicians to reconsider whether patients should undergo radiotherapy without locate first the recurrence.
Citation	González-San Segundo C, Gómez-Iturriaga A, Couñago F. Are all prostate cancer patients "fit" for salvage radiotherapy? World J Clin Oncol 2020; 11(1): 1-10

Received	2019-07-05 00:43
Peer-Review Started	2019-07-17 08:51
To Make the First Decision	2019-10-15 00:20
Return for Revision	2019-10-15 00:50
Revised	2019-11-13 09:10
Second Decision	2019-11-15 08:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-11-19 04:19
Articles in Press	2019-11-19 04:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-12-18 07:19

ISSN	2218-4333 (online)
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