Publication Name	World Journal of Clinical Cases
Manuscript ID	50910
Country	China

Category	Medicine, Research & Experimental
Manuscript Type	Case Report
Article Title	Mixed serous-neuroendocrine neoplasm of the pancreas: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Yue-Mei Xu, Zhi-Wen Li, Hong-Yan Wu, Xiang-Shan Fan and Qi Sun
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81702596
Corresponding Author	Qi Sun, MD, PhD, Doctor, Department of Pathology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, Jiangsu Province, China. blkqisun@qq.com
Key Words	Mixed serous-neuroendocrine neoplasm; Pancreatic serous cystic neoplasm; Pancreatic neuroendocrine tumor; Von Hippel-Lindau syndrome; Case report;
Core Tip	Mixed serous-neuroendocrine neoplasm (MSNN). MSNNs are a mixed tumor containing 2 components with different pathologies, namely pancreatic serous cystic neoplasms (PSCN) and pancreatic neuroendocrine tumor (PanNET). For MSNNs, Diffuse PSCN involving the whole pancreas is extremely rare with only 8 previous case reports. Here, we report a new case of Diffuse PSCN admixture with an isolated PanNET in a Chinese woman, and also review the previous literature. Due to its close relationship with Von Hippel-Lindau syndrome, and the malignant potential of neuroendocrine component, patients with MSNN should undergo thorough systemic examination, including molecular genetic analysis, and close clinical follow-up is also recommended.
Citation	Xu YM, Li ZW, Wu HY, Fan XS, Sun Q. Mixed serous-neuroendocrine neoplasm of the pancreas: A case report and review of the literature. World J Clin Cases 2019; 7(23): 4119-4129

Received	2019-08-22 06:30
Peer-Review Started	2019-08-22 06:31
To Make the First Decision	2019-09-27 01:20
Return for Revision	2019-09-30 08:50
Revised	2019-10-14 15:35
Second Decision	2019-11-14 08:55
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-11-15 01:56
Articles in Press	2019-11-15 01:56
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-11-19 09:27
Typeset the Manuscript	2019-12-02 02:17

ISSN	2307-8960 (online)
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