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11/15/2019 1:54:05 AM | Browse: 207 | Download: 385
Publication Name World Journal of Clinical Cases
Manuscript ID 51045
Country/Territory China
Category Urology & Nephrology
Manuscript Type Case Control Study
Article Title Human podocyte injury in the early course of hypertensive renal injury
Manuscript Source Unsolicited Manuscript
All Author List Da Sun, Jiao-Jiao Wang, Wei Wang, Juan Wang, Li-Ning Wang, Li Yao, Ying-Hui Sun and Zi-Long Li
Funding Agency and Grant Number
Funding Agency Grant Number
Natural Science Foundation of Liaoning Provincial Department of Science and Technology 2017225020
Corresponding Author Ying-Hui Sun, MD, Associate Chief Physician, Department of Experimental Medicine, General Hospital of Northern Theater Command, No. 83 Wenhua Road, Shenhe District, Shenyang 110016, Liaoning Province, China. yinghui_sun@163.com
Key Words Podocyte; Hypertension; Hypertensive renal injury; Microalbuminuria; Nephrin; CD2-associated protein
Core Tip Podocytes probably play a crucial role in the pathogenesis of hypertensive renal injury, but human data are limited. In this study, we detected podocytes from urine sediments of patients with chronic hypertension and trace proteinuria, and obtained direct evidence that podocyte loss is not only associated with severe renal damage in chronic hypertension, but also occurs in the early course of hypertensive renal injury. We found that intrarenal expression of nephrin and CD2-associated protein was downregulated and consistent with podocyte shedding.
Citation Sun D, Wang JJ, Wang W, Wang J, Wang LN, Yao L, Sun YH, Li ZL. Human podocyte injury in the early course of hypertensive renal injury. World J Clin Cases 2019; 7(22): 3698-3710
Received
2019-09-08 12:49
Peer-Review Started
2019-09-08 12:49
To Make the First Decision
2019-10-24 09:29
Return for Revision
2019-10-30 00:59
Revised
2019-11-03 03:58
Second Decision
2019-11-14 06:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-11-15 01:54
Articles in Press
2019-11-15 01:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-11-21 11:20
Typeset the Manuscript
2019-11-22 07:43
ISSN 2307-8960 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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