Publication Name	World Journal of Gastroenterology
Manuscript ID	51410
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Irisin attenuates intestinal injury, oxidative and endoplasmic reticulum stress in mice with L-arginine-induced acute pancreatitis
Manuscript Source	Unsolicited Manuscript
All Author List	Yi-Fan Ren, Meng-Zhou Wang, Jian-Bin Bi, Jia Zhang, Lin Zhang, Wu-Ming Liu, Sha-Sha Wei, Yi Lv, Zheng Wu and Rong-Qian Wu
Funding Agency and Grant Number	Funding Agency Grant Number National Nature Science Foundation of China 81770491 Ministry of Education Innovation Team Development Program of China IRT16R57
Corresponding Author	Rong-Qian Wu, MD, PhD, Professor, National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, First Affiliated Hospital of Xi'an Jiaotong University, No. 76 West Yanta Road, Xi’an 710061, Shaanxi Province, China. rwu001@mail.xjtu.edu.cn
Key Words	Irisin; Intestinal injury; Oxidative stress; Endoplasmic reticulum stress; Acute pancreatitis; Mouse model
Core Tip	In this study, we reported for the first time that intraperitoneal injection of irisin could relieve intestinal injury in mice with acute pancreatitis (AP). AP was induced in male adult mice by 2 hourly intraperitoneal injections of L-arginine. At 2 h after the last injection of L-arginine, irisin (50 or 250 μg/kg body weight) or 1 mL normal saline (vehicle) was administered through intraperitoneal injection. Irisin alleviates intestinal and systemic inflammatory reactions by inhibiting intestinal endoplasmic reticulum stress and oxidative stress in mice with AP, reduces the degree of intestinal tissue apoptosis and injury, and finally alleviates the condition of pancreatitis.
Citation	Ren YF, Wang MZ, Bi JB, Zhang J, Zhang L, Liu WM, Wei SS, Lv Y, Wu Z, Wu RQ. Irisin attenuates intestinal injury, oxidative and endoplasmic reticulum stress in mice with L-arginine-induced acute pancreatitis. World J Gastroenterol 2019; 25(45): 6653-6667

Received	2019-09-17 08:33
Peer-Review Started	2019-09-17 08:34
To Make the First Decision	2019-11-04 07:40
Return for Revision	2019-11-05 00:22
Revised	2019-11-08 04:50
Second Decision	2019-11-15 11:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-11-16 02:14
Articles in Press	2019-11-16 02:14
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-11-27 00:17
Typeset the Manuscript	2019-12-02 10:46

ISSN	1007-9327 (print) and 2219-2840 (online)
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