| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Bacterial infection triggers and complicates acute-on-chronic liver failure in patients with hepatitis B virus-decompensated cirrhosis: A retrospective cohort study
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Zhu-Jun Cao, Yu-Han Liu, Chuan-Wu Zhu, Shan Yin, Wei-Jing Wang, Wei-Liang Tang, Gang-De Zhao, Yu-Min Xu, Lu Chen, Tian-Hui Zhou, Ming-Hao Cai, Hui Wang, Wei Cai, Shi-San Bao, Hai Li and Qing Xie |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81570535 |
| National Natural Science Foundation of China |
81770587 |
| Key Projects in the National Science & Technology Pillar Program during the Thirteenth Five-year Plan Period |
2017ZX10203201-008 |
| Key Projects in the National Science & Technology Pillar Program during the Thirteenth Five-year Plan Period |
2018ZX09206005-003 |
| Key Projects in the National Science & Technology Pillar Program during the Thirteenth Five-year Plan Period |
2017ZX10202202-005-004 |
| Shanghai Three-Year Plan of the Clinical Skills and Innovations |
16CR1002A |
| Shanghai Clinical Key Specialty Construction Project (Infectious Diseases) |
shslczdzk01103; |
| Shanghai Three-Year Plan of the Key Subjects Construction in Public Health-Infectious Diseases and Pathogenic Microorganism |
15GWZK0102 |
| Suzhou Expert Team of Clinical Medicine |
SZYJTD201717 |
| Joint Research Initiative-Shanghai Jiao Tong University School of Medicine and the Shanghai Municipal Key Clinical Specialty-Infectious disease |
YW20190002 |
|
| Corresponding Author |
Qing Xie, MD, PhD, Chief Physician, Professor, Department of Infectious diseases, Shanghai Jiaotong University, School of Medicine, No. 36 Building, No.197 Ruijin 2nd Road, Shanghai 200025, China. xq10403@rjh.com.cn |
| Key Words |
Hepatitis B virus; Cirrhosis; Decompensation; Bacterial infection; Acute-on-chronic liver failure; Survival |
| Core Tip |
In our cohort of 1281 patients with hepatitis B virus-related decompensated cirrhosis, bacterial infection (BI) significantly reduced both short-term and long-term survival independently of the presence of Acute-on-chronic liver failure (ACLF) and the severity of the underlying liver disease. BI would precipitate ACLF in patients admitted without this syndrome and in those with ACLF, BI was significantly associated with the reduced rate of liver transplantation. Thus, the data suggests that patients with hepatitis B virus-DC should be monitored carefully for the development of BI to avoid an adverse outcome. |
| Citation |
Cao ZJ, Liu YH, Zhu CW, Yin S, Wang WJ, Tang WL, Zhao GD, Xu YM, Chen L, Zhou TH, Cai MH, Wang H, Cai W, Bao SS, Li H, Xie Q. Bacterial infection triggers and complicates acute-on-chronic liver failure in patients with hepatitis B virus-decompensated cirrhosis: A retrospective cohort study. World J Gastroenterol 2020; 26(6): 645-656 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
