Publication Name	World Journal of Clinical Cases
Manuscript ID	51691
Country	Romania

Category	Medicine, General & Internal
Manuscript Type	Prospective Study
Article Title	Interaction of arylsulfatases A and B with maspin: A possible explanation for dysregulation of tumor cell metabolism and invasive potential of colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Zsolt Kovacs, Ioan Jung, Krisztina Szalman, Laura Banias, Tivadar Jr Bara and Simona Gurzu
Funding Agency and Grant Number	Funding Agency Grant Number the Romanian National Authority for Scientific Research, CNCSIS – UEFISCDI 20 PCCF/2018
Corresponding Author	Simona Gurzu, MD, PhD, Chief Doctor, Director, Doctor, Full Professor, Research Fellow, Research Scientist, Department of Pathology, University of Medicine, Pharmacy, Sciences and Technology, “George Emil Palade“, 38 Gheorghe Marinescu Street, Targu Mures 540139, Romania. simonagurzu@yahoo.com
Key Words	Arylsulfatase; Maspin; Colorectal cancer; ARSB gene; Blood; Tissue
Core Tip	In this paper we tried to emphasize the role of ARSA and ARSB in colorectal cancer (CRC) beahaviour and possible role of ARSB serum level in follow-up of patients. This is the first study in literature which proved that a low ARSB gene expression in serum (RQ < 1) might be a non-invasive indicator of risk of CRC. Moreover, triple positivity for maspin/ARSA/ARSB and ARSB gene expression level < 0.5 were proved to be indicators of CRC aggressive behavior, independent of lymph node status.
Citation	Kovacs Z, Jung I, Szalman K, Banias L, Bara TJ, Gurzu S. Interaction of arylsulfatases A and B with maspin: A possible explanation for dysregulation of tumor cell metabolism and invasive potential of colorectal cancer. World J Clin Cases 2020; 7(23): 3990-4003

Received	2019-09-27 16:18
Peer-Review Started	2019-09-27 16:18
To Make the First Decision	2019-10-24 09:37
Return for Revision	2019-10-25 02:34
Revised	2019-10-31 18:39
Second Decision	2019-11-14 10:55
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-11-15 01:40
Articles in Press	2019-11-15 01:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-11-21 10:30

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which selected by an in-house editor and fully peer-reviewed by external reviewers. It distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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