| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Basic Study |
| Article Title |
Pentadecapeptide BPC 157 resolves Pringle maneuver in rats, both ischemia and reperfusion
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Marijan Kolovrat, Slaven Gojkovic, Ivan Krezic, Dominik Malekinusic, Borna Vrdoljak, Katarina Kasnik Kovac, Tamara Kralj, Domagoj Drmic, Ivan Barisic, Katarina Horvat Pavlov, Andreja Petrovic, Antonija Duzel, Mario Knezevic, Ivan Mirkovic, Antonio Kokot, Alenka Boban Blagaic, Sven Seiwerth and Predrag Sikiric |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Predrag Sikiric, MD, PhD, Professor, Departments of Pharmacology and Pathology, School of Medicine, University of Zagreb, POB 916, Salata 11, Zagreb 10000, Croatia. sikiric@mef.hr |
| Key Words |
BPC 157; Pringle maneuver; Rats; Portal hypertension; Caval hypertension; Ischemia |
| Core Tip |
Recently, cytoprotective agent BPC 157 successfully resolved vessel occlusions in rats (ischemic colitis; deep vein thrombosis, superior anterior pancreaticoduodenal vein) through rapid collateral vessel recruitment to circumvent vessel occlusion. Medication BPC 157 [(10 µg, 10 ng/kg) regimens, administered as a single challenge] picked (1) ischemia, portal triad obstruction (PTO) period [at 5 min before (ip) or at 5 or 30 min of ligation time (as a bath to PTO)] or (2) reperfusion, post-PTO period [at 1 or 15 min (bath during surgery) or 24 h (ip) reperfusion time]. Gross, microscopy, malondialdehyde, serum enzymes, electrocardiogram, portal, caval and aortal pressure, thrombosis and venography assessments demonstrated that BPC 157 successfully attenuates ischemia-reperfusion injury of the liver and other organs. In particular, BPC 157 rapidly activates portocaval shunt, normalises arterial and disturbed blood pressure (portal and caval hypertension and aortal hypotension), counteracts formation of blood clots and cardiac rhythm changes and counteracts gastrointestinal mucosal lesions, as complications that follow the Pringle maneuver. |
| Citation |
Kolovrat M, Gojkovic S, Krezic I, Malekinusic D, Vrdoljak B, Kasnik Kovac K, Kralj T, Drmic D, Barisic I, Horvat Pavlov K, Petrovic A, Duzel A, Knezevic M, Mirkovic I, Kokot A, Boban Blagaic A, Seiwerth S, Sikiric P. Pentadecapeptide BPC 157 resolves Pringle maneuver in rats, both ischemia and reperfusion. World J Hepatol 2020; 12(5): 184-206 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
