Publication Name	World Journal of Gastroenterology
Manuscript ID	52041
Country	India

Category	Oncology
Manuscript Type	Basic Study
Article Title	Histone deacetylase inhibitor pretreatment enhances efficacy of DNA-interacting chemo-drugs in gastric cancer
Manuscript Source	Invited Manuscript
All Author List	Ramchandra Vijay Amnekar, Shafqat Ali Khan, Mudasir Rashid, Bharat Khade, Rahul Thorat, Poonam Gera, Shailesh V Shrikhande, Duane T Smoot, Hassan Ashktorab and Sanjay Gupta
Funding Agency and Grant Number	Funding Agency Grant Number TMH-IRG 466/2012 and 164/2016 LTMT
Corresponding Author	Sanjay Gupta, PhD, Senior Scientist, Epigenetics and Chromatin Biology Group, Gupta Laboratory, Cancer Research Institute, Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai 410210, Maharashtra, India. sgupta@actrec.gov.in
Key Words	Chemotherapy; Combinatorial index; Gastric cancer; Histone acetylation; Histone deacetylase inhibitor; Patient stratification
Core Tip	Our study suggest that pre-treatment with histone deacetylase inhibitors (HDACi) in a pre-clinical model of gastric cancer increase acetylation, opens chromatin and favors binding of DNA interacting chemotherapeutic drugs synergistically. This enhances cytotoxic potential of chemotherapeutic drug at low therapeutic dose and reduces toxicity. The dose response studies using Fa plots and median curve analysis proposes valproic acid as the most synergistic and effective HDACi in combination with platinum based drugs. Further, HDAC expression or activity based patient stratification prior to HDACi therapy has been put forth for better clinical outcome of chemotherapeutic drugs in solid tumors.
Citation	Amnekar RV, Khan SA, Rashid M, Khade B, Thorat R, Gera P, Shrikhande SV, Smoot DT, Ashktorab H and Gupta S. Histone deacetylase inhibitor pretreatment enhances efficacy of DNA-interacting chemo-drugs in gastric cancer. World J Gastroenterol 2020; 26(6): 598-613

Received	2019-10-15 09:51
Peer-Review Started	2019-10-15 09:52
To Make the First Decision
Return for Revision	2019-12-04 20:08
Revised	2019-12-20 12:39
Second Decision	2020-01-11 03:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-01-14 19:56
Articles in Press	2020-01-14 19:56
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-01-18 23:43
Typeset the Manuscript	2020-02-13 00:22

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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