Publication Name	World Journal of Gastroenterology
Manuscript ID	52223
Country	Japan

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Pre-hepatectomy type IV collagen 7S predicts post-hepatectomy liver failure and recovery
Manuscript Source	Unsolicited Manuscript
All Author List	Masatsugu Ishii, Osamu Itano, Masahiro Shinoda, Minoru Kitago, Yuta Abe, Taizo Hibi, Hiroshi Yagi, Ayano Takeuchi, Hanako Tsujikawa, Tokiya Abe and Yuko Kitagawa
Funding Agency and Grant Number
Corresponding Author	Osamu Itano, MD, PhD, Professor, Surgeon, Department of Hepato-Biliary-Pancreatic and Gastrointestinal Surgery, International University of Health and Welfare School of Medicine, 3-4-1Mita Minato-ku, Tokyo 108-8329, Japan. laplivertiger@gmail.com
Key Words	Hepatectomy; Liver failure; Type IV collagen 7S; Liver fibrosis; Postoperative complications; Long-term postoperative liver function recovery
Core Tip	In this study, we identified the pre-hepatectomy factor associated with both early postoperative liver failure and long-term postoperative liver function recovery. We found that preoperative type IV collagen 7S is a significant independent factor associated with both post-hepatectomy liver failure and postoperative long-term recovery of liver function. Our analysis revealed that the time required for the recovery of Child–Pugh scores and serum total bilirubin and total bilirubin levels was significantly shorter in patients with type IV collagen 7S ≤ 6 ng/mL than in patients with type IV collagen 7S > 6 ng/mL.
Citation	Ishii M, Itano O, Shinoda M, Kitago M, Abe Y, Hibi T, Yagi H, Takeuchi A, Tsujikawa H, Abe T, Kitagawa Y. Pre-hepatectomy type IV collagen 7S predicts post-hepatectomy liver failure and recovery. World J Gastroenterol 2020; 26(7): 725-739

Received	2019-11-22 07:44
Peer-Review Started	2019-11-22 07:44
To Make the First Decision
Return for Revision	2019-12-07 03:45
Revised	2020-01-11 15:14
Second Decision	2020-01-18 08:07
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-01-18 18:44
Articles in Press	2020-01-18 18:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-02-17 01:22

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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