| Category |
Medical Laboratory Technology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Serum N-glycan markers for diagnosing liver fibrosis induced by hepatitis B virus
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xi Cao, Qing-Hua Shang, Xiao-Ling Chi, Wei Zhang, Huan-Ming Xiao, Mi-Mi Sun, Gang Chen, Yong An, Chun-Lei Lv, Lin Wang, Yue-Min Nan, Cui-Ying Chen, Zong-Nan Tan, Xue-En Liu and Hui Zhuang |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Xue-En Liu, MD, PhD, Academic Research, Associate Professor, Department of Microbiology and Center of Infectious Diseases, School of Basic Medical Sciences, Peking University Health Science Center, No. 38 Xueyuan Road, Haidian District, Beijing 100191, China. xueenliu@bjmu.edu.cn |
| Key Words |
Chronic hepatitis B; Liver fibrosis; N-glycan; Multiparameter diagnostic models; Receiver operating characteristic curve analysis; Diagnostic power |
| Core Tip |
GlycoFibroTest and GlycoCirrhoTest were unsuitable for assessing fibrosis stages induced by HBV. We built three multiparameter diagnostic models based on serum N-glycans in HBV related fibrosis patients and combined them with ALT and PLT for distinguishing liver fibrosis F0-F1 from F2-F4, F0-F2 from F3-F4 and F0-F3 from F4, and the excellent diagnostic power was obtained (AUROC=0.912, 0.829 and 0.885, respectively). In addition, three combined models were verified in the validation group and diagnostic accuracies still high (AUROC=0.909, 0.858 and 0.867, respectively). Moreover, our combined models also could be used to discriminate adjacent fibrosis stages (F0-1/F2/F3/F4) (AUROC=0.917, 0.720 and 0.785, respectively). |
| Citation |
Cao X, Shang QH, Chi XL, Zhang W, Xiao HM, Sun MM, Chen G, An Y, Lv CL, Wang L, Nan YM, Chen CY, Tan ZN, Liu XE, Zhuang H. Serum N-glycan markers for diagnosing liver fibrosis induced by hepatitis B virus. World J Gastroenterol 2020; 26(10): 1067-1079 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
