Publication Name	World Journal of Clinical Cases
Manuscript ID	52529
Country	Italy

Category	Oncology
Manuscript Type	Case Report
Article Title	Can cyclin-dependent kinase 4/6 inhibitors convert inoperable breast cancer relapse to operability? A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Michela Palleschi, Roberta Maltoni, Eleonora Barzotti, Elisabetta Melegari, Annalisa Curcio, Lorenzo Cecconetto, Samanta Sarti, Silvia Manunta and Andrea Rocca
Funding Agency and Grant Number
Corresponding Author	Michela Palleschi, MD, Doctor, Department of Medical Oncology, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Via P. Maroncelli 40, Meldola 47014, Italy. michela.palleschi@irst.emr.it
Key Words	Hormone receptor-positive advanced breast cancer; Endocrine therapy; Cyclin-dependent kinase 4/6 inhibitor; Pathological complete response; ;
Core Tip	The rate of pathological complete response (pCR) after endocrine therapy (ET) in hormone receptor-positive breast cancer is low, limiting the value of pCR as a surrogate endpoint for the effectiveness of this treatment. Moreover, radical resection of locoregional recurrence is difficult to achieve when the tumor invades critical structures, e.g. blood vessels. Several studies have evaluated whether ET could also be used as a research platform for testing novel drugs in patients with ER-positive disease.
Citation	Palleschi M, Maltoni R, Barzotti E, Melegari E, Curcio A, Cecconetto L, Sarti S, Manunta S, Rocca A. Can cyclin-dependent kinase 4/6 inhibitors convert inoperable breast cancer relapse to operability? A case report. World J Clin Cases 2020; 8(3): 517-521

Received	2019-12-05 07:49
Peer-Review Started	2019-12-03 12:21
To Make the First Decision
Return for Revision	2019-12-23 09:32
Revised	2020-01-09 15:59
Second Decision	2020-01-11 06:29
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-01-14 19:02
Articles in Press	2020-01-14 19:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-01-18 05:16

ISSN	2307-8960 (online)
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