Publication Name	World Journal of Gastroenterology
Manuscript ID	52542
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Celecoxib attenuates hepatocyte apoptosis by inhibiting endoplasmic reticulum stress in thioacetamide-induced cirrhotic rats
Manuscript Source	Unsolicited Manuscript
All Author List	Wei Su, Yang Tai, Shi-Hang Tang, Yan-Ting Ye, Chong Zhao, Jin-Hang Gao, Bi-Guang Tuo and Cheng-Wei Tang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Fund of China U1702281 National Natural Science Fund of China 81670551 National Natural Science Fund of China 81873584
Corresponding Author	Cheng-Wei Tang, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology, West China Hospital, Sichuan University, No. 37, Guo Xue Lane, Chengdu 610041, Sichuan Province, China. shcqcdmed@163.com
Key Words	Liver fibrosis; Endoplasmic reticulum stress; Celecoxib; Cyclooxygenase-2; CCAAT/enhancer binding protein homologous protein; Apoptosis
Core Tip	This study aims to explore the important role of celecoxib in modulating hepatocyte apoptosis during the development of liver fibrosis; to clarify that the mechanism of its regulation is mediated by endoplasmic reticulum stress, which in turn affects the progress of liver fibrosis. We concluded that therapeutic administration of celecoxib can effectively reduce hepatic apoptosis in thioacetamide-induced cirrhotic rats. The mechanism of action may be attributed to the suppression of CCAAT/enhancer binding protein homologous protein expression, which subsequently inhibited endoplasmic reticulum stress.
Citation	Su W, Tai Y, Tang SH, Ye YT, Zhao C, Gao JH, Tuo BG, Tang CW. Celecoxib attenuates hepatocyte apoptosis by inhibiting endoplasmic reticulum stress in thioacetamide-induced cirrhotic rats. World J Gastroenterol 2020; 26(28): 4094-4107

Received	2020-01-30 13:49
Peer-Review Started	2020-01-30 13:50
To Make the First Decision
Return for Revision	2020-04-22 23:33
Revised	2020-05-21 13:04
Second Decision	2020-06-24 08:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-06-25 04:54
Articles in Press	2020-06-25 04:54
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-07-03 02:23
Typeset the Manuscript	2020-07-28 07:32

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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