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Publication Name World Journal of Gastroenterology
Manuscript ID 52691
Country/Territory China
Category Gastroenterology & Hepatology
Manuscript Type Prospective Study
Article Title Technetium-99m-labeled macroaggregated albumin lung perfusion scan for diagnosis of hepatopulmonary syndrome: A prospective study comparing brain uptake and whole-body uptake
Manuscript Source Unsolicited Manuscript
All Author List He Zhao, Jiaywei Tsauo, Xiao-Wu Zhang, Huai-Yuan Ma, Ning-Na Weng, Gong-Shun Tang and Xiao Li
Funding Agency and Grant Number
Funding Agency Grant Number
National Key R and D Program of China 2017YFC0107800
CAMS Initiative for Innovative Medicine 2016-12M-2-004
Corresponding Author Xiao Li, MD, PhD, Doctor, Postdoc, Professor, Department of Interventional Therapy, National Cancer Center/National Clinical Research Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. simonlixiao@gmail.com
Key Words Portal Hypertension; Intrapulmonary Vascular Dilations; Radionuclide Imaging; Technetium-99m-labeled Macroaggregated albumin Lung Perfusion Scan; Diagnostic Tests; Sensitivity and Specificity
Core Tip Hepatopulmonary syndrome is a common complication of liver disease which impairs the lungs’ ability to oxygenate blood, leading to debilitating symptoms, such as shortness of breath. Intrapulmonary vascular dilations, a hallmark of hepatopulmonary syndrome, can be detected using technetium-99m-labeled macroaggregated albumin lung perfusion scan, however, of the two most commonly used methods of result interpretation (i.e., brain uptake and whole-body uptake), it is unclear which is more accurate. In this study of 69 patients with liver cirrhosis, we found that whole-body uptake is more accurate than brain uptake for detecting intrapulmonary vascular dilations.
Citation Zhao H, Tsauo J, Zhang X, Ma H, Weng N, Tang G, Li X. Technetium-99m-labeled macroaggregated albumin lung perfusion scan for diagnosis of hepatopulmonary syndrome: A prospective study comparing brain uptake and whole-body uptake. World J Gastroenterol 2020; 26(10): 1088-1097
Received
2019-11-14 03:03
Peer-Review Started
2019-11-14 03:03
To Make the First Decision
Return for Revision
2019-12-30 22:17
Revised
2020-01-06 07:58
Second Decision
2020-01-18 10:01
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-01-18 18:47
Articles in Press
2020-01-18 18:47
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-02-19 23:18
Typeset the Manuscript
2020-03-13 09:02
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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