Publication Name	World Journal of Clinical Cases
Manuscript ID	52726
Country	South Korea

Category	Oncology
Manuscript Type	Case Report
Article Title	Acute myeloid leukemia with t(11;19)(q23;p13.1) in a patient with a gastrointestinal stromal tumor undergoing imatinib therapy: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Hong Jun Kim, Sun Kyung Baek, Chi Hoon Maeng, Si-Young Kim, Tae Sung Park and Jae Joon Han
Funding Agency and Grant Number
Corresponding Author	Jae Joon Han, MD, PhD, Professor, Department of Hematology and Medical oncology, Kyung Hee University, Kyungheedae-Ro 23, Dongdaemoon-Gu, Seoul 02447, South Korea. anemia@khu.ac.kr
Key Words	Acute myeloid leukemia; Gastrointestinal stromal tumor; Imatinib; KMT2A; Myelodysplastic syndrome; Case report
Core Tip	To the best of our knowledge, this is the first report of acute myeloid leukemia with KMT2A gene rearrangements in a patient with a gastrointestinal stromal tumor receiving imatinib mesylate (IM) treatment. Although there is no known mechanism by which IM causes acute leukemia, there have been reports supporting the speculation that IM may have a direct mutagenic effect on normal hematopoietic precursors. Physicians should consider the potential risks of developing hematologic malignancies, including therapy-related acute myeloid leukemia, in patients with gastrointestinal stromal tumors receiving IM treatment.
Citation	Kim HJ, Baek SK, Maeng CH, Kim SY, Park TS, Han JJ. Acute myeloid leukemia with t(11;19)(q23;p13.1) in a patient with a gastrointestinal stromal tumor undergoing imatinib therapy: A case report. World J Clin Cases 2020; 8(7): 1251-1256

Received	2019-11-15 08:39
Peer-Review Started	2019-11-15 08:40
To Make the First Decision
Return for Revision	2020-02-20 23:32
Revised	2020-03-20 08:44
Second Decision	2020-03-26 12:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-03-26 21:14
Articles in Press	2020-03-26 21:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-04-03 12:07

ISSN	2307-8960 (online)
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