Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	52958
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Prognostic significance of systemic immune-inflammation index in patients with intrahepatic cholangiocarcinoma undergoing hepatic resection
Manuscript Source	Unsolicited Manuscript
All Author List	Hui Li, Jin-Ju Wang, Min Zhang, Bo Ren, Jia-Xin Li, Lin Xu and Hong Wu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81972747 National Natural Science Foundation of China 81872004 National Natural Science Foundation of China 81800564 National Natural Science Foundation of China 81770615 National Natural Science Foundation of China 81700555 National Natural Science Foundation of China 81672882 Science and Technology Support Program of Sichuan Province 2019YFQ0001 Science and Technology Support Program of Sichuan Province 2018SZ0115 Science and Technology Support Program of Sichuan Province 2017SZ0003 Science and Technology Program of Tibet Autonomous Region XZ201801-GB-02 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University ZYJC18008
Corresponding Author	Hong Wu, MD, PhD, Professor, Surgeon, Department of Liver Surgery and Liver Transplantation, West China Hospital of Sichuan University, No.37 Guoxue Lane, Wuhou District, Chengdu 610041, Sichuan Province, China. wuhong7801@163.com
Key Words	Intrahepatic cholangiocarcinoma; Systemic immune-inflammation index; Hepatectomy; Prognostic predictor; Long-term outcomes; Immunotherapy
Core Tip	Inflammation has been reported to play a crucial role in tumor biology. Systemic immune-inflammation index (SII), an inflammation-based index, was a composite measure of neutrophil, platelet and lymphocyte counts. No data exists until now, has evaluated its prognostic value for intrahepatc cholangiocarcinoma (ICC). This study aimed to investigate the clinical significance of preoperative SII levels in ICC patients undergoing curative resection. Patients with increased SII level were associated with worse overall survival and earlier tumor recurrence. In the future, the SII could help stratifying patients with ICC, thus guiding therapeutic choices, especially in immunotherapy.
Citation	Li H, Wang JJ, Zhang M, Ren B, Li JX, Xu L, Wu H. Prognostic significance of systemic immune-inflammation index in patients with intrahepatic cholangiocarcinoma undergoing hepatic resection. World J Gastrointest Oncol 2020; 12(4): 467-482

Received	2019-12-13 12:13
Peer-Review Started	2019-12-13 12:13
To Make the First Decision	2020-03-11 00:55
Return for Revision	2020-03-11 05:59
Revised	2020-03-11 15:34
Second Decision	2020-03-25 10:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-03-26 21:34
Articles in Press	2020-03-26 21:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-04-14 01:39

ISSN	1948-5204 (online)
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