Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	52967
Country	United Kingdom

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Pancreatic exocrine insufficiency after pancreaticoduodenectomy: Current evidence and management
Manuscript Source	Invited Manuscript
All Author List	Adithya M Pathanki, Joseph A Attard, Elizabeth Bradley, Sarah Powell-Brett, Bobby V M Dasari, John R Isaac, Keith J Roberts and Nikolaos A Chatzizacharias
Funding Agency and Grant Number
Corresponding Author	Nikolaos A Chatzizacharias, FRCS (Gen Surg), MD, PhD, Surgeon, Department of HPB and liver transplantation, Queen Elizabeth Hospital, University Hospitals Birmingham, 3rd Floor, Nuffield House, Mindelsohn way, Birmingham B15 2TH, United Kingdom. chatzizacharias@gmail.com
Key Words	Pancreatic exocrine insufficiency; Pancreaticoduodenectomy; Pancreatic enzyme replacement therapy; Pancreatic cancer; Malabsorption; Steatorrhoea
Core Tip	Pancreatic exocrine insufficiency is highly prevalent after pancreaticoduodenectomy and has significant implications to patients’ quality of life, nutrition, post-operative survival and cancer related outcomes. The published literature reveals no uniform definition of pancreatic exocrine insufficiency in this setting and patients are often underdiagnosed. Pancreatic enzyme replacement therapy is effective, well tolerated and is indicated in this cohort of patients either routinely or at diagnosis of exocrine insufficiency. Future studies need to concentrate on the identification of a well-tolerated, reliable and reproducible diagnostic test in this setting.
Citation	Pathanki AM, Attard JA, Bradley E, Powell-Brett S, Dasari BVM, Isaac JR, Roberts KJ, Chatzizacharias NA. Pancreatic exocrine insufficiency after pancreaticoduodenectomy: Current evidence and management. World J Gastrointest Pathophysiol 2020; 11(2): 20-31

Received	2019-12-02 18:08
Peer-Review Started	2019-12-02 18:09
To Make the First Decision
Return for Revision	2019-12-23 16:39
Revised	2020-03-13 21:45
Second Decision	2020-03-19 10:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-03-22 21:42
Articles in Press	2020-03-22 21:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-04-08 02:45

ISSN	2150-5330 (online)
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